Oral microbiome composition reflects prospective risk for esophageal cancers

Brandilyn A. Peters, Jing Wu, Zhiheng Pei, Liying Yang, Mark P. Purdue, Neal D. Freedman, Eric J. Jacobs, Susan M. Gapstur, Richard B. Hayes, Jiyoung Ahn

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Bacteria may play a role in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), although evidence is limited to cross-sectional studies. In this study, we examined the relationship of oral microbiota with EAC and ESCC risk in a prospective study nested in two cohorts. Oral bacteria were assessed using 16S rRNA gene sequencing in prediagnostic mouthwash samples from n ¼ 81/160 EAC and n ¼ 25/50 ESCC cases/matched controls. Findings were largely consistent across both cohorts. Metagenome content was predicted using PiCRUST. We examined associations between centered log-ratio transformed taxon or functional pathway abundances and risk using conditional logistic regression adjusting for BMI, smoking, and alcohol. We found the periodontal pathogen Tannerella forsythia to be associated with higher risk of EAC. Furthermore, we found that depletion of the commensal genus Neisseria and the species Streptococcus pneumoniae was associated with lower EAC risk. Bacterial biosynthesis of carotenoids was also associated with protection against EAC. Finally, the abundance of the periodontal pathogen Porphyromonas gingivalis trended with higher risk of ESCC. Overall, our findings have potential implications for the early detection and prevention of EAC and ESCC.

Original languageEnglish (US)
Pages (from-to)6777-6787
Number of pages11
JournalCancer Research
Volume77
Issue number23
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

Fingerprint

Microbiota
Esophageal Neoplasms
Adenocarcinoma
Metagenome
Mouthwashes
Bacteria
Neisseria
Porphyromonas gingivalis
Carotenoids
Streptococcus pneumoniae
rRNA Genes
Cross-Sectional Studies
Logistic Models
Smoking
Alcohols
Esophageal Squamous Cell Carcinoma
Prospective Studies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Peters, B. A., Wu, J., Pei, Z., Yang, L., Purdue, M. P., Freedman, N. D., ... Ahn, J. (2017). Oral microbiome composition reflects prospective risk for esophageal cancers. Cancer Research, 77(23), 6777-6787. https://doi.org/10.1158/0008-5472.CAN-17-1296

Oral microbiome composition reflects prospective risk for esophageal cancers. / Peters, Brandilyn A.; Wu, Jing; Pei, Zhiheng; Yang, Liying; Purdue, Mark P.; Freedman, Neal D.; Jacobs, Eric J.; Gapstur, Susan M.; Hayes, Richard B.; Ahn, Jiyoung.

In: Cancer Research, Vol. 77, No. 23, 01.12.2017, p. 6777-6787.

Research output: Contribution to journalArticle

Peters, BA, Wu, J, Pei, Z, Yang, L, Purdue, MP, Freedman, ND, Jacobs, EJ, Gapstur, SM, Hayes, RB & Ahn, J 2017, 'Oral microbiome composition reflects prospective risk for esophageal cancers', Cancer Research, vol. 77, no. 23, pp. 6777-6787. https://doi.org/10.1158/0008-5472.CAN-17-1296
Peters, Brandilyn A. ; Wu, Jing ; Pei, Zhiheng ; Yang, Liying ; Purdue, Mark P. ; Freedman, Neal D. ; Jacobs, Eric J. ; Gapstur, Susan M. ; Hayes, Richard B. ; Ahn, Jiyoung. / Oral microbiome composition reflects prospective risk for esophageal cancers. In: Cancer Research. 2017 ; Vol. 77, No. 23. pp. 6777-6787.
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