Oral human papillomavirus detection in older adults who have human immunodeficiency virus infection

Mahnaz Fatahzadeh, Nicolas F. Schlecht, Zigui Chen, Danielle Bottalico, Sharod McKinney, Janae Ostoloza, Anne Dunne, Robert D. Burk

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To evaluate reproducibility of oral rinse self-collection for human papillomavirus (HPV) detection and investigate associations between oral HPV, oral lesions, immune and sociodemographic factors, we performed a cross-sectional study of older adults with human immunodeficiency virus (HIV) infection. Study Design: We collected oral rinse samples from 52 subjects at 2 different times of day, followed by an oral examination and interview. We identified HPV with the use of polymerase chain reaction platforms optimized for detection of mucosal and cutaneous types. Results: Eighty-seven percent of individuals had oral HPV, of which 23% had oncogenic alpha, 40% had nononcogenic alpha, and 46% had beta or gamma HPV. Paired oral specimens were concordant in all parameters tested. Significant associations observed for oral HPV with increased HIV viral load, hepatitis C seropositivity, history of sexually transmitted diseases, and lifetime number of sexual partners. Conclusions: Oral cavity may be a reservoir of subclinical HPV in older adults who have HIV infection. Understanding natural history, transmission, and potential implications of oral HPV warrants further investigations.

Original languageEnglish (US)
Pages (from-to)505-514
Number of pages10
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume115
Issue number4
DOIs
StatePublished - Apr 2013

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Virus Diseases
HIV
Oral Diagnosis
Sexual Partners
Immunologic Factors
Hepatitis C
Sexually Transmitted Diseases
Natural History
Viral Load
Mouth
Cross-Sectional Studies
Interviews
Polymerase Chain Reaction
Skin

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Dentistry (miscellaneous)

Cite this

Oral human papillomavirus detection in older adults who have human immunodeficiency virus infection. / Fatahzadeh, Mahnaz; Schlecht, Nicolas F.; Chen, Zigui; Bottalico, Danielle; McKinney, Sharod; Ostoloza, Janae; Dunne, Anne; Burk, Robert D.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 115, No. 4, 04.2013, p. 505-514.

Research output: Contribution to journalArticle

Fatahzadeh, Mahnaz ; Schlecht, Nicolas F. ; Chen, Zigui ; Bottalico, Danielle ; McKinney, Sharod ; Ostoloza, Janae ; Dunne, Anne ; Burk, Robert D. / Oral human papillomavirus detection in older adults who have human immunodeficiency virus infection. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2013 ; Vol. 115, No. 4. pp. 505-514.
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