TY - JOUR
T1 - Oral human papillomavirus detection in older adults who have human immunodeficiency virus infection
AU - Fatahzadeh, Mahnaz
AU - Schlecht, Nicolas F.
AU - Chen, Zigui
AU - Bottalico, Danielle
AU - McKinney, Sharod
AU - Ostoloza, Janae
AU - Dunne, Anne
AU - Burk, Robert D.
N1 - Funding Information:
Supported in part by the National Cancer Institute ( CA78527 , to R.D.B.), National Institute for Dental and Craniofacial Research ( DE021671 , to N.F.S.), the Einstein-Montefiore Center for AIDS funded by the National Institutes of Health ( AI051519 ), the Einstein Cancer Research Center ( P30-CA013330 ) funded by the National Cancer Institute, and the New Jersey Dental School Department of Diagnostic Sciences.
PY - 2013/4
Y1 - 2013/4
N2 - Objective: To evaluate reproducibility of oral rinse self-collection for human papillomavirus (HPV) detection and investigate associations between oral HPV, oral lesions, immune and sociodemographic factors, we performed a cross-sectional study of older adults with human immunodeficiency virus (HIV) infection. Study Design: We collected oral rinse samples from 52 subjects at 2 different times of day, followed by an oral examination and interview. We identified HPV with the use of polymerase chain reaction platforms optimized for detection of mucosal and cutaneous types. Results: Eighty-seven percent of individuals had oral HPV, of which 23% had oncogenic alpha, 40% had nononcogenic alpha, and 46% had beta or gamma HPV. Paired oral specimens were concordant in all parameters tested. Significant associations observed for oral HPV with increased HIV viral load, hepatitis C seropositivity, history of sexually transmitted diseases, and lifetime number of sexual partners. Conclusions: Oral cavity may be a reservoir of subclinical HPV in older adults who have HIV infection. Understanding natural history, transmission, and potential implications of oral HPV warrants further investigations.
AB - Objective: To evaluate reproducibility of oral rinse self-collection for human papillomavirus (HPV) detection and investigate associations between oral HPV, oral lesions, immune and sociodemographic factors, we performed a cross-sectional study of older adults with human immunodeficiency virus (HIV) infection. Study Design: We collected oral rinse samples from 52 subjects at 2 different times of day, followed by an oral examination and interview. We identified HPV with the use of polymerase chain reaction platforms optimized for detection of mucosal and cutaneous types. Results: Eighty-seven percent of individuals had oral HPV, of which 23% had oncogenic alpha, 40% had nononcogenic alpha, and 46% had beta or gamma HPV. Paired oral specimens were concordant in all parameters tested. Significant associations observed for oral HPV with increased HIV viral load, hepatitis C seropositivity, history of sexually transmitted diseases, and lifetime number of sexual partners. Conclusions: Oral cavity may be a reservoir of subclinical HPV in older adults who have HIV infection. Understanding natural history, transmission, and potential implications of oral HPV warrants further investigations.
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U2 - 10.1016/j.oooo.2012.11.004
DO - 10.1016/j.oooo.2012.11.004
M3 - Article
C2 - 23375488
AN - SCOPUS:84875367506
SN - 2212-4403
VL - 115
SP - 505
EP - 514
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 4
ER -
