Optimal timing of radiotherapy in high risk prostate cancer: Do missed days matter?

Shaakir Hasan, Daniel Gorovets, Eric Lehrer, Stanislav Lazarev, Robert H. Press, Madhur Garg, Keyur J. Mehta, Arpit M. Chhabra, J. Isabelle Choi, Charles B. Simone

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: High-risk prostate cancer is associated with poorer overall survival (OS) and biochemical control compared to more favorable risk groups. External beam radiation therapy (EBRT) is widely used; however, outcomes data are limited with respect to time elapsed between diagnosis and initiation of EBRT. Methods: The National Cancer Database was queried from 2004 to 2015 for patients diagnosed with high-risk adenocarcinoma of the prostate who received androgen deprivation therapy (ADT) and definitive EBRT. Logistic regression was utilized to determine covariates associated with missing EBRT treatments. OS was analyzed using multivariate cox proportional hazards models and propensity score matching. Results: 9,610 patients met inclusion criteria with median follow-up of 40.6 months and median age of 72 years. Median PSA was 8.7 and median EBRT dose was 78 Gy. ADT was initiated at a median of 36 days and EBRT at a median of 63 days post-diagnosis. Median number of prolonged treatment days was 2.2. Black race (OR: 1.40; p < 0.01), treatment at a community clinic (OR: 1.32; p < 0.01), and living in an urban/densely populated area were associated with prolonged treatment. Time elapsed between ADT and EBRT > 74 days (HR: 1.20; p = 0.01) and prolonged treatment>3 days of EBRT (HR: 1.26; p = 0.005) were associated with an increased hazard of death. The 5-year OS was 79.6% and 82.9% for patients with prolonged treatment of 3 days or more of EBRT and those missing 3 days or less, respectively (p = 0.0006). Conclusion: In this hypothesis-generating study, prolonged treatment delays and missing three or more EBRT treatments was associated with poorer OS in patients with high-risk adenocarcinoma of the prostate.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalClinical and Translational Radiation Oncology
Volume26
DOIs
StatePublished - Jan 2021
Externally publishedYes

Keywords

  • Androgen deprivation therapy
  • External beam radiation therapy
  • Prostate cancer
  • Radiation oncology
  • Survival
  • Urology

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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