Optical recording of action potentials and other discrete physiological events: A perspective from signal detection theory

Lucas L. Sjulson, Gero Miesenböck

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Optical imaging of physiological events in real time can yield insights into biological function that would be difficult to obtain by other experimental means. However, the detection of all-or-none events, such as action potentials or vesicle fusion events, in noisy single-trial data often requires a careful balance of tradeoffs. The analysis of such experiments, as well as the design of optical reporters and instrumentation for them, is aided by an understanding of the principles of signal detection. This review illustrates these principles, using as an example action potential recording with optical voltage reporters.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalPhysiology
Volume22
Issue number1
DOIs
StatePublished - Feb 1 2007
Externally publishedYes

Fingerprint

Action Potentials
Optical Imaging
Psychological Signal Detection

ASJC Scopus subject areas

  • Physiology

Cite this

Optical recording of action potentials and other discrete physiological events : A perspective from signal detection theory. / Sjulson, Lucas L.; Miesenböck, Gero.

In: Physiology, Vol. 22, No. 1, 01.02.2007, p. 47-55.

Research output: Contribution to journalReview article

@article{5e15efd0947d46e6bddeeae2b90f4d76,
title = "Optical recording of action potentials and other discrete physiological events: A perspective from signal detection theory",
abstract = "Optical imaging of physiological events in real time can yield insights into biological function that would be difficult to obtain by other experimental means. However, the detection of all-or-none events, such as action potentials or vesicle fusion events, in noisy single-trial data often requires a careful balance of tradeoffs. The analysis of such experiments, as well as the design of optical reporters and instrumentation for them, is aided by an understanding of the principles of signal detection. This review illustrates these principles, using as an example action potential recording with optical voltage reporters.",
author = "Sjulson, {Lucas L.} and Gero Miesenb{\"o}ck",
year = "2007",
month = "2",
day = "1",
doi = "10.1152/physiol.00036.2006",
language = "English (US)",
volume = "22",
pages = "47--55",
journal = "Physiology",
issn = "1548-9213",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Optical recording of action potentials and other discrete physiological events

T2 - A perspective from signal detection theory

AU - Sjulson, Lucas L.

AU - Miesenböck, Gero

PY - 2007/2/1

Y1 - 2007/2/1

N2 - Optical imaging of physiological events in real time can yield insights into biological function that would be difficult to obtain by other experimental means. However, the detection of all-or-none events, such as action potentials or vesicle fusion events, in noisy single-trial data often requires a careful balance of tradeoffs. The analysis of such experiments, as well as the design of optical reporters and instrumentation for them, is aided by an understanding of the principles of signal detection. This review illustrates these principles, using as an example action potential recording with optical voltage reporters.

AB - Optical imaging of physiological events in real time can yield insights into biological function that would be difficult to obtain by other experimental means. However, the detection of all-or-none events, such as action potentials or vesicle fusion events, in noisy single-trial data often requires a careful balance of tradeoffs. The analysis of such experiments, as well as the design of optical reporters and instrumentation for them, is aided by an understanding of the principles of signal detection. This review illustrates these principles, using as an example action potential recording with optical voltage reporters.

UR - http://www.scopus.com/inward/record.url?scp=33847137384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847137384&partnerID=8YFLogxK

U2 - 10.1152/physiol.00036.2006

DO - 10.1152/physiol.00036.2006

M3 - Review article

C2 - 17289930

AN - SCOPUS:33847137384

VL - 22

SP - 47

EP - 55

JO - Physiology

JF - Physiology

SN - 1548-9213

IS - 1

ER -