Abstract
A preliminary result supports the feasibility of using visible light to modulate the membrane potential of a cell. Human embryonic kidney cells (HEK293) were transfected with vertebrate rhodopsin and a gradient inward rectifying potassium (GIRK) channel. Whole cell patch clamp recordings of HEK293 cells exposed to 9-cis retinal showed that illumination increases the potassium current compared with recordings obtained in the dark. When combined with a rapid scanning device, this approach has the potential to control the activity of many neurons.
| Original language | English (US) |
|---|---|
| Article number | 49 |
| Pages (from-to) | 197-207 |
| Number of pages | 11 |
| Journal | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Volume | 5 |
| Issue number | 13 |
| DOIs | |
| State | Published - 2004 |
| Event | Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XI - San Jose, CA, United States Duration: Jan 27 2004 → Jan 29 2004 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging
- Biomaterials