TY - JOUR
T1 - Opposite genetic effects of CMIP polymorphisms on the risk of type 2 diabetes and obesity
T2 - A family-based study in China
AU - Cao, Yaying
AU - Wang, Tao
AU - Wu, Yiqun
AU - Juan, Juan
AU - Qin, Xueying
AU - Tang, Xun
AU - Wu, Tao
AU - Hu, Yonghua
N1 - Funding Information:
Acknowledgments: We would like to express our gratitude to all the participants of this study for their cooperation as well as valuable contributions and to all the staff at Beijing Fangshan District Center for Disease Control for their help during the implementation of our study. This study was supported by grants from the Key Project of Natural Science Funds of China (81230066) and the National Natural Science Foundation of China (81473043).
Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/4
Y1 - 2018/4
N2 - C-Maf Inducing Protein (CMIP) gene polymorphisms were reported to be associated with type 2 diabetes mellitus (T2DM). Whether the association between CMIP and T2DM is mediated via obesity-related phenotypes is still unclear. We analyzed the association of CMIP rs2925979 with T2DM and a comprehensive set of obesity-related phenotypes in 1576 families ascertained from a Chinese population. These families included a total of 3444 siblings (1582 with T2DM, 963 with prediabetes, and 899 with a normal glucose level). Using multi-level mixed effects regression models, we found that each copy of CMIP rs2925979_T allele was associated with a 29% higher risk of T2DM in females (p = 9.30 × 10−4), while it was not significantly associated with T2DM in males (p = 0.705). Meanwhile, rs2925979_T allele was associated with lower levels of body mass index (BMI), waist circumference (WC), hip circumference (HC), percentage of body fat (PBF), PBF of arms, PBF of legs, and PBF of trunk in nondiabetes females (all p < 0.05). The opposite associations of rs2925979_T allele with T2DM and obesity-related phenotypes suggest that CMIP may exert independent pleiotropic effects on T2DM and obesity-related phenotypes in females.
AB - C-Maf Inducing Protein (CMIP) gene polymorphisms were reported to be associated with type 2 diabetes mellitus (T2DM). Whether the association between CMIP and T2DM is mediated via obesity-related phenotypes is still unclear. We analyzed the association of CMIP rs2925979 with T2DM and a comprehensive set of obesity-related phenotypes in 1576 families ascertained from a Chinese population. These families included a total of 3444 siblings (1582 with T2DM, 963 with prediabetes, and 899 with a normal glucose level). Using multi-level mixed effects regression models, we found that each copy of CMIP rs2925979_T allele was associated with a 29% higher risk of T2DM in females (p = 9.30 × 10−4), while it was not significantly associated with T2DM in males (p = 0.705). Meanwhile, rs2925979_T allele was associated with lower levels of body mass index (BMI), waist circumference (WC), hip circumference (HC), percentage of body fat (PBF), PBF of arms, PBF of legs, and PBF of trunk in nondiabetes females (all p < 0.05). The opposite associations of rs2925979_T allele with T2DM and obesity-related phenotypes suggest that CMIP may exert independent pleiotropic effects on T2DM and obesity-related phenotypes in females.
KW - CMIP
KW - Family-based study
KW - Obesity
KW - Pleiotropic genetic effects
KW - Sex-specific pattern
KW - Type 2 diabetes mellitus
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U2 - 10.3390/ijms19041011
DO - 10.3390/ijms19041011
M3 - Article
C2 - 29597287
AN - SCOPUS:85044623473
SN - 1661-6596
VL - 19
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 4
M1 - 1011
ER -
