Opposite associations of trunk and leg fat depots with plasma ferritin levels in middle-aged and older chinese men and women

Hongyu Wu, Qibin Qi, Zhijie Yu, Liang Sun, Huaixing Li, Xu Lin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Few data have been published on the associations of ferritin with trunk and leg fat depots. We aimed to investigate these associations in a Chinese population. Methodology: Trunk fat mass and leg fat mass were determined in a cross-sectional sample of 1,150 Chinese (479 men and 671 women) aged 50-70 years by dual-energy X-ray absorptiometry scan. Fasting plasma ferritin was measured. Principal Findings: Plasma ferritin was positively correlated with waist circumference, waist-to-hip ratio, total body fat and trunk fat mass, but inversely correlated with leg fat mass in men (r = 0.16, 0.26, 0.19, 0.22 and -0.12, respectively, all P<0.05) and women (r = 0.16, 0.16, 0.08, 0.17 and <0.12, respectively, all P<0.05). Multivariate regression analysis showed that ferritin levels increased with larger trunk fat mass (β = 0.33 ± 0.08 for men and β = 0.21 ± 0.05 for women, both P<0.001) while decreased with larger leg fat mass (β = -0.12 ± 0.09, P = 0.15 for men; and β = -0.14 ± 0.05, P = 0.005 for women). Moreover, plasma ferritin levels decreased with increasing tertile of leg fat mass among each tertile of trunk fat mass. Conclusion: This is the first study to report the opposite associations of trunk and leg fat depots with plasma ferritin levels. Copyright:

Original languageEnglish (US)
Article numbere13316
JournalPLoS One
Volume5
Issue number10
DOIs
StatePublished - Oct 13 2010
Externally publishedYes

Fingerprint

middle-aged adults
ferritin
Ferritins
Leg
legs
Fats
Plasmas
lipids
waist-to-hip ratio
dual-energy X-ray absorptiometry
Waist-Hip Ratio
waist circumference
Photon Absorptiometry
Waist Circumference
body fat
fasting
Regression analysis
Adipose Tissue
Fasting
regression analysis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Opposite associations of trunk and leg fat depots with plasma ferritin levels in middle-aged and older chinese men and women. / Wu, Hongyu; Qi, Qibin; Yu, Zhijie; Sun, Liang; Li, Huaixing; Lin, Xu.

In: PLoS One, Vol. 5, No. 10, e13316, 13.10.2010.

Research output: Contribution to journalArticle

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abstract = "Background: Few data have been published on the associations of ferritin with trunk and leg fat depots. We aimed to investigate these associations in a Chinese population. Methodology: Trunk fat mass and leg fat mass were determined in a cross-sectional sample of 1,150 Chinese (479 men and 671 women) aged 50-70 years by dual-energy X-ray absorptiometry scan. Fasting plasma ferritin was measured. Principal Findings: Plasma ferritin was positively correlated with waist circumference, waist-to-hip ratio, total body fat and trunk fat mass, but inversely correlated with leg fat mass in men (r = 0.16, 0.26, 0.19, 0.22 and -0.12, respectively, all P<0.05) and women (r = 0.16, 0.16, 0.08, 0.17 and <0.12, respectively, all P<0.05). Multivariate regression analysis showed that ferritin levels increased with larger trunk fat mass (β = 0.33 ± 0.08 for men and β = 0.21 ± 0.05 for women, both P<0.001) while decreased with larger leg fat mass (β = -0.12 ± 0.09, P = 0.15 for men; and β = -0.14 ± 0.05, P = 0.005 for women). Moreover, plasma ferritin levels decreased with increasing tertile of leg fat mass among each tertile of trunk fat mass. Conclusion: This is the first study to report the opposite associations of trunk and leg fat depots with plasma ferritin levels. Copyright:",
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