OPPORTUNISTIC LYMPHOPROLIFERATIONS ASSOCIATED WITH EPSTEIN-BARR VIRAL DNA IN INFANTS AND CHILDREN WITH AIDS

Warren A. Andiman; Kelsey Martin; Arye Rubinstein; Savita Pahwa; Robin Eastman; Ben Z. Katz; Jane Pitt; George Miller

doi:10.1016/S0140-6736(85)92557-7

OPPORTUNISTIC LYMPHOPROLIFERATIONS ASSOCIATED WITH EPSTEIN-BARR VIRAL DNA IN INFANTS AND CHILDREN WITH AIDS

Warren A. Andiman, Kelsey Martin, Arye Rubinstein, Savita Pahwa, Robin Eastman, Ben Z. Katz, Jane Pitt, George Miller

Pediatrics

Research output: Contribution to journal › Article › peer-review

166 Scopus citations

Abstract

Two types of lymphoproliferative disease associated with Epstein-Barr viral (EBV) DNA-central-nervous-system lymphoma and chronic lymphocytic interstitial pneumonitis (LIP)-were recognised in children with human T-lymphotropic virus type III/lymphadenopathy virus infection and the acquired immunodeficiency syndrome (AIDS). Eight of ten lung biopsy specimens from children with LIP contained EBV DNA. EBV DNA was not identified in lung biopsy specimens with Pneumocystis carinii, cytomegalovirus, or atypical mycobacteria but without LIP, nor was EBV found in lung biopsy specimens from five adults with AIDS. Children with these EBV-associated complications had raised serum antibody titres to the replicative EBV antigens, but most of them lacked antibody to the component of the EB nuclear antigen encoded by the Bam HI K fragment. EBV-associated lymphoproliferative disease is a common and important complication of childhood AIDS.

Original language	English (US)
Pages (from-to)	1390-1393
Number of pages	4
Journal	The Lancet
Volume	326
Issue number	8469-8470
DOIs	https://doi.org/10.1016/S0140-6736(85)92557-7
State	Published - Dec 28 1985

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General Medicine

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title = "OPPORTUNISTIC LYMPHOPROLIFERATIONS ASSOCIATED WITH EPSTEIN-BARR VIRAL DNA IN INFANTS AND CHILDREN WITH AIDS",

abstract = "Two types of lymphoproliferative disease associated with Epstein-Barr viral (EBV) DNA-central-nervous-system lymphoma and chronic lymphocytic interstitial pneumonitis (LIP)-were recognised in children with human T-lymphotropic virus type III/lymphadenopathy virus infection and the acquired immunodeficiency syndrome (AIDS). Eight of ten lung biopsy specimens from children with LIP contained EBV DNA. EBV DNA was not identified in lung biopsy specimens with Pneumocystis carinii, cytomegalovirus, or atypical mycobacteria but without LIP, nor was EBV found in lung biopsy specimens from five adults with AIDS. Children with these EBV-associated complications had raised serum antibody titres to the replicative EBV antigens, but most of them lacked antibody to the component of the EB nuclear antigen encoded by the Bam HI K fragment. EBV-associated lymphoproliferative disease is a common and important complication of childhood AIDS.",

author = "Andiman, {Warren A.} and Kelsey Martin and Arye Rubinstein and Savita Pahwa and Robin Eastman and Katz, {Ben Z.} and Jane Pitt and George Miller",

note = "Funding Information: This work was supported by National and AI 21186.",

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AU - Andiman, Warren A.

AU - Martin, Kelsey

AU - Rubinstein, Arye

AU - Pahwa, Savita

AU - Eastman, Robin

AU - Katz, Ben Z.

AU - Pitt, Jane

AU - Miller, George

N1 - Funding Information: This work was supported by National and AI 21186.

PY - 1985/12/28

Y1 - 1985/12/28

N2 - Two types of lymphoproliferative disease associated with Epstein-Barr viral (EBV) DNA-central-nervous-system lymphoma and chronic lymphocytic interstitial pneumonitis (LIP)-were recognised in children with human T-lymphotropic virus type III/lymphadenopathy virus infection and the acquired immunodeficiency syndrome (AIDS). Eight of ten lung biopsy specimens from children with LIP contained EBV DNA. EBV DNA was not identified in lung biopsy specimens with Pneumocystis carinii, cytomegalovirus, or atypical mycobacteria but without LIP, nor was EBV found in lung biopsy specimens from five adults with AIDS. Children with these EBV-associated complications had raised serum antibody titres to the replicative EBV antigens, but most of them lacked antibody to the component of the EB nuclear antigen encoded by the Bam HI K fragment. EBV-associated lymphoproliferative disease is a common and important complication of childhood AIDS.

AB - Two types of lymphoproliferative disease associated with Epstein-Barr viral (EBV) DNA-central-nervous-system lymphoma and chronic lymphocytic interstitial pneumonitis (LIP)-were recognised in children with human T-lymphotropic virus type III/lymphadenopathy virus infection and the acquired immunodeficiency syndrome (AIDS). Eight of ten lung biopsy specimens from children with LIP contained EBV DNA. EBV DNA was not identified in lung biopsy specimens with Pneumocystis carinii, cytomegalovirus, or atypical mycobacteria but without LIP, nor was EBV found in lung biopsy specimens from five adults with AIDS. Children with these EBV-associated complications had raised serum antibody titres to the replicative EBV antigens, but most of them lacked antibody to the component of the EB nuclear antigen encoded by the Bam HI K fragment. EBV-associated lymphoproliferative disease is a common and important complication of childhood AIDS.

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IS - 8469-8470

ER -

OPPORTUNISTIC LYMPHOPROLIFERATIONS ASSOCIATED WITH EPSTEIN-BARR VIRAL DNA IN INFANTS AND CHILDREN WITH AIDS

Abstract

ASJC Scopus subject areas

UN SDGs

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