Operative management of islet-cell tumors arising in the head of the pancreas

B. J. Park, H. R. Alexander, S. K. Libutti, J. Huang, D. Royalty, M. C. Skarulis, R. T. Jensen, P. Gorden, J. L. Doppman, T. H. Shawker, D. L. Fraker, J. A. Norton, D. L. Bartlett, E. C. Ellison, C. Proye, M. J. Demeure, N. W. Thompson

Research output: Contribution to journalArticle

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Abstract

Background. Pancreatic islet cell tumors (ICTs) can be treated by enucleation or pancreatic resection. We reviewed our experience with ICTs in the head of the pancreas to define indications for enucleation versus pancreaticoduodenectomy. Methods. Between January 1982 and December 1997, 48 patients underwent surgical resection for presumed ICTs of the pancreatic head. Of these, 18 were found on pathologic examination to be disease in a lymph node. Thirty patients had 32 true pancreatic head ICTs. We reviewed the operative results and postoperative courses in these patients. Results. Mean diameter of the ICTs was 15 mm. Twenty-seven patients (90%) underwent successful enucleations. Three patients failed enucleation and underwent pancreaticoduodenectomy. There was no operative mortality. The median time to regular diet was 7 days. The median time to removal of all drains was 22 days. The most common complication was pancreatic fistula (15%). No patient required reoperation for treatment of a fistula. Conclusion. Most ICTs of the pancreatic head can be removed with enucleation, preserving pancreatic tissue and avoiding the morbidity of pancreaticoduodenectomy. The primary indication for pancreaticoduodenectomy is not the size of the lesion but its proximity to the pancreatic duct.

Original languageEnglish (US)
Pages (from-to)1056-1062
Number of pages7
JournalSurgery
Volume124
Issue number6
DOIs
StatePublished - 1998
Externally publishedYes

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Islet Cell Adenoma
Pancreas
Pancreaticoduodenectomy
Pancreatic Fistula
Pancreatic Ducts
Reoperation
Fistula
Lymph Nodes
Diet
Morbidity
Mortality
Pancreatic islet cell tumors

ASJC Scopus subject areas

  • Surgery

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Park, B. J., Alexander, H. R., Libutti, S. K., Huang, J., Royalty, D., Skarulis, M. C., ... Thompson, N. W. (1998). Operative management of islet-cell tumors arising in the head of the pancreas. Surgery, 124(6), 1056-1062. https://doi.org/10.1067/msy.1998.92171

Operative management of islet-cell tumors arising in the head of the pancreas. / Park, B. J.; Alexander, H. R.; Libutti, S. K.; Huang, J.; Royalty, D.; Skarulis, M. C.; Jensen, R. T.; Gorden, P.; Doppman, J. L.; Shawker, T. H.; Fraker, D. L.; Norton, J. A.; Bartlett, D. L.; Ellison, E. C.; Proye, C.; Demeure, M. J.; Thompson, N. W.

In: Surgery, Vol. 124, No. 6, 1998, p. 1056-1062.

Research output: Contribution to journalArticle

Park, BJ, Alexander, HR, Libutti, SK, Huang, J, Royalty, D, Skarulis, MC, Jensen, RT, Gorden, P, Doppman, JL, Shawker, TH, Fraker, DL, Norton, JA, Bartlett, DL, Ellison, EC, Proye, C, Demeure, MJ & Thompson, NW 1998, 'Operative management of islet-cell tumors arising in the head of the pancreas', Surgery, vol. 124, no. 6, pp. 1056-1062. https://doi.org/10.1067/msy.1998.92171
Park BJ, Alexander HR, Libutti SK, Huang J, Royalty D, Skarulis MC et al. Operative management of islet-cell tumors arising in the head of the pancreas. Surgery. 1998;124(6):1056-1062. https://doi.org/10.1067/msy.1998.92171
Park, B. J. ; Alexander, H. R. ; Libutti, S. K. ; Huang, J. ; Royalty, D. ; Skarulis, M. C. ; Jensen, R. T. ; Gorden, P. ; Doppman, J. L. ; Shawker, T. H. ; Fraker, D. L. ; Norton, J. A. ; Bartlett, D. L. ; Ellison, E. C. ; Proye, C. ; Demeure, M. J. ; Thompson, N. W. / Operative management of islet-cell tumors arising in the head of the pancreas. In: Surgery. 1998 ; Vol. 124, No. 6. pp. 1056-1062.
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abstract = "Background. Pancreatic islet cell tumors (ICTs) can be treated by enucleation or pancreatic resection. We reviewed our experience with ICTs in the head of the pancreas to define indications for enucleation versus pancreaticoduodenectomy. Methods. Between January 1982 and December 1997, 48 patients underwent surgical resection for presumed ICTs of the pancreatic head. Of these, 18 were found on pathologic examination to be disease in a lymph node. Thirty patients had 32 true pancreatic head ICTs. We reviewed the operative results and postoperative courses in these patients. Results. Mean diameter of the ICTs was 15 mm. Twenty-seven patients (90{\%}) underwent successful enucleations. Three patients failed enucleation and underwent pancreaticoduodenectomy. There was no operative mortality. The median time to regular diet was 7 days. The median time to removal of all drains was 22 days. The most common complication was pancreatic fistula (15{\%}). No patient required reoperation for treatment of a fistula. Conclusion. Most ICTs of the pancreatic head can be removed with enucleation, preserving pancreatic tissue and avoiding the morbidity of pancreaticoduodenectomy. The primary indication for pancreaticoduodenectomy is not the size of the lesion but its proximity to the pancreatic duct.",
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AU - Park, B. J.

AU - Alexander, H. R.

AU - Libutti, S. K.

AU - Huang, J.

AU - Royalty, D.

AU - Skarulis, M. C.

AU - Jensen, R. T.

AU - Gorden, P.

AU - Doppman, J. L.

AU - Shawker, T. H.

AU - Fraker, D. L.

AU - Norton, J. A.

AU - Bartlett, D. L.

AU - Ellison, E. C.

AU - Proye, C.

AU - Demeure, M. J.

AU - Thompson, N. W.

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N2 - Background. Pancreatic islet cell tumors (ICTs) can be treated by enucleation or pancreatic resection. We reviewed our experience with ICTs in the head of the pancreas to define indications for enucleation versus pancreaticoduodenectomy. Methods. Between January 1982 and December 1997, 48 patients underwent surgical resection for presumed ICTs of the pancreatic head. Of these, 18 were found on pathologic examination to be disease in a lymph node. Thirty patients had 32 true pancreatic head ICTs. We reviewed the operative results and postoperative courses in these patients. Results. Mean diameter of the ICTs was 15 mm. Twenty-seven patients (90%) underwent successful enucleations. Three patients failed enucleation and underwent pancreaticoduodenectomy. There was no operative mortality. The median time to regular diet was 7 days. The median time to removal of all drains was 22 days. The most common complication was pancreatic fistula (15%). No patient required reoperation for treatment of a fistula. Conclusion. Most ICTs of the pancreatic head can be removed with enucleation, preserving pancreatic tissue and avoiding the morbidity of pancreaticoduodenectomy. The primary indication for pancreaticoduodenectomy is not the size of the lesion but its proximity to the pancreatic duct.

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