Ontogenic aspects of mammalian inner ear development

T. R. Van De Water, C. W. Li, Robert J. Ruben, C. A. Shea

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Organ culture of a mammalian inner ear was first applied to analysis of the factors influencing ontogeny of the inner ear by Van De Water and Ruben. At present this provides a model system with which the mechanisms that control normal development and congenital malformation of the inner ear may be investigated. This presentation reports the current state of knowledge of mechanisms influencing ontogeny of the mammalian inner ear as derived from organ culture experiments and discusses experimental data on the subjects of a) neurotrophic interactions, b) experiments on endolymphatic duct and sac anlage, c) fate mapping, d) neural induction, and e) epithelial/mesenchymal interactions.

Original languageEnglish (US)
Pages (from-to)5-45
Number of pages41
JournalBirth Defects: Original Article Series
Volume16
Issue number4
StatePublished - 1980

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Inner Ear
Organ Culture Techniques
Endolymphatic Duct
Endolymphatic Sac
Statistical Factor Analysis
Water

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics(clinical)

Cite this

Van De Water, T. R., Li, C. W., Ruben, R. J., & Shea, C. A. (1980). Ontogenic aspects of mammalian inner ear development. Birth Defects: Original Article Series, 16(4), 5-45.

Ontogenic aspects of mammalian inner ear development. / Van De Water, T. R.; Li, C. W.; Ruben, Robert J.; Shea, C. A.

In: Birth Defects: Original Article Series, Vol. 16, No. 4, 1980, p. 5-45.

Research output: Contribution to journalArticle

Van De Water, TR, Li, CW, Ruben, RJ & Shea, CA 1980, 'Ontogenic aspects of mammalian inner ear development', Birth Defects: Original Article Series, vol. 16, no. 4, pp. 5-45.
Van De Water, T. R. ; Li, C. W. ; Ruben, Robert J. ; Shea, C. A. / Ontogenic aspects of mammalian inner ear development. In: Birth Defects: Original Article Series. 1980 ; Vol. 16, No. 4. pp. 5-45.
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