One-pot thioether formation from S -nitrosothiols

Dehui Zhang, Nelmi O. Devarie-Baez, Jia Pan, Hua Wang, Ming Xian

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Protein S-nitrosation is an important post-translational modification. However, the detection of S-nitrosation is still problematic because S-nitrosation products, that is, S-nitrosothiols, are unstable species. Here a new reaction which can selectively convert unstable S-nitrosothiols to stable thioethers in one-pot under very mild conditions is reported. This reaction has the potential to be applied in the detection of protein S-nitrosation.

Original languageEnglish (US)
Pages (from-to)5674-5676
Number of pages3
JournalOrganic Letters
Volume12
Issue number24
DOIs
StatePublished - Dec 17 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Zhang, D., Devarie-Baez, N. O., Pan, J., Wang, H., & Xian, M. (2010). One-pot thioether formation from S -nitrosothiols. Organic Letters, 12(24), 5674-5676. https://doi.org/10.1021/ol102491n