One-pot thioether formation from S -nitrosothiols

Dehui Zhang, Nelmi O. Devarie-Baez, Jia Pan, Hua Wang, Ming Xian

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Protein S-nitrosation is an important post-translational modification. However, the detection of S-nitrosation is still problematic because S-nitrosation products, that is, S-nitrosothiols, are unstable species. Here a new reaction which can selectively convert unstable S-nitrosothiols to stable thioethers in one-pot under very mild conditions is reported. This reaction has the potential to be applied in the detection of protein S-nitrosation.

Original languageEnglish (US)
Pages (from-to)5674-5676
Number of pages3
JournalOrganic Letters
Volume12
Issue number24
DOIs
StatePublished - Dec 17 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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