Oncogenic human papillomavirus infection and cervical lesions in aboriginal women of Nunavut, Canada

Sylvia M. Healey, Kristan J. Aronson, Yang Mao, Nicolas F. Schlecht, Leslie S. Mery, Alex Ferenczy, Eduardo L. Franco

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background: The high rate of cervical cancer among aboriginal women of northern Canada has prompted the search for more aggressive methods to augment Papanicolaou (Pap) screening in this population. Nearly all cervical cancers result from oncogenic human papillomavirus (HPV) infections. This has generated interest for incorporating HPV testing into the current screening program. Goals: To determine the prevalence of oncogenic HPVs in Nunavut, and to assess the association between HPV and squamous intraepithelial lesions (SIL). Study Design: A cross-sectional study was conducted on the Pap-screened populations in 19 communities of Nunavut, Canada. Liquid-based cytology was used to screen for SIL. HPV testing was performed using the Hybrid Capture II assay. Correlates of HPV infection and SIL were assessed by logistic regression with control for potential confounders. Results: In 1290 women ages 13 to 79 years, the prevalence rate was 26% for oncogenic HPV and 6.9% for SIL. The odds ratio for the association between HPV and SIL was 37.9 (95% CI, 17.7-80.8) after multivariate adjustment. This association increased markedly with increasing viral load. More than 90% of the women with squamous intraepithelial lesions had positive test results for HPV. More than 75% of the women who had positive test results for HPV but negative test results for SIL were younger than 30 years. Conclusion: The results of this study form the basis for further evaluation of the role that liquid-based cytology and HPV testing plays and will contribute to the strategy for cervical cancer prevention in Nunavut.

Original languageEnglish (US)
Pages (from-to)694-700
Number of pages7
JournalSexually Transmitted Diseases
Volume28
Issue number12
StatePublished - 2001
Externally publishedYes

Fingerprint

Nunavut
Papillomavirus Infections
Canada
Uterine Cervical Neoplasms
Cell Biology
Squamous Intraepithelial Lesions of the Cervix
Viral Load
Population

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)

Cite this

Healey, S. M., Aronson, K. J., Mao, Y., Schlecht, N. F., Mery, L. S., Ferenczy, A., & Franco, E. L. (2001). Oncogenic human papillomavirus infection and cervical lesions in aboriginal women of Nunavut, Canada. Sexually Transmitted Diseases, 28(12), 694-700.

Oncogenic human papillomavirus infection and cervical lesions in aboriginal women of Nunavut, Canada. / Healey, Sylvia M.; Aronson, Kristan J.; Mao, Yang; Schlecht, Nicolas F.; Mery, Leslie S.; Ferenczy, Alex; Franco, Eduardo L.

In: Sexually Transmitted Diseases, Vol. 28, No. 12, 2001, p. 694-700.

Research output: Contribution to journalArticle

Healey, SM, Aronson, KJ, Mao, Y, Schlecht, NF, Mery, LS, Ferenczy, A & Franco, EL 2001, 'Oncogenic human papillomavirus infection and cervical lesions in aboriginal women of Nunavut, Canada', Sexually Transmitted Diseases, vol. 28, no. 12, pp. 694-700.
Healey SM, Aronson KJ, Mao Y, Schlecht NF, Mery LS, Ferenczy A et al. Oncogenic human papillomavirus infection and cervical lesions in aboriginal women of Nunavut, Canada. Sexually Transmitted Diseases. 2001;28(12):694-700.
Healey, Sylvia M. ; Aronson, Kristan J. ; Mao, Yang ; Schlecht, Nicolas F. ; Mery, Leslie S. ; Ferenczy, Alex ; Franco, Eduardo L. / Oncogenic human papillomavirus infection and cervical lesions in aboriginal women of Nunavut, Canada. In: Sexually Transmitted Diseases. 2001 ; Vol. 28, No. 12. pp. 694-700.
@article{f3a7081fa2fd424db185e3ee77f16295,
title = "Oncogenic human papillomavirus infection and cervical lesions in aboriginal women of Nunavut, Canada",
abstract = "Background: The high rate of cervical cancer among aboriginal women of northern Canada has prompted the search for more aggressive methods to augment Papanicolaou (Pap) screening in this population. Nearly all cervical cancers result from oncogenic human papillomavirus (HPV) infections. This has generated interest for incorporating HPV testing into the current screening program. Goals: To determine the prevalence of oncogenic HPVs in Nunavut, and to assess the association between HPV and squamous intraepithelial lesions (SIL). Study Design: A cross-sectional study was conducted on the Pap-screened populations in 19 communities of Nunavut, Canada. Liquid-based cytology was used to screen for SIL. HPV testing was performed using the Hybrid Capture II assay. Correlates of HPV infection and SIL were assessed by logistic regression with control for potential confounders. Results: In 1290 women ages 13 to 79 years, the prevalence rate was 26{\%} for oncogenic HPV and 6.9{\%} for SIL. The odds ratio for the association between HPV and SIL was 37.9 (95{\%} CI, 17.7-80.8) after multivariate adjustment. This association increased markedly with increasing viral load. More than 90{\%} of the women with squamous intraepithelial lesions had positive test results for HPV. More than 75{\%} of the women who had positive test results for HPV but negative test results for SIL were younger than 30 years. Conclusion: The results of this study form the basis for further evaluation of the role that liquid-based cytology and HPV testing plays and will contribute to the strategy for cervical cancer prevention in Nunavut.",
author = "Healey, {Sylvia M.} and Aronson, {Kristan J.} and Yang Mao and Schlecht, {Nicolas F.} and Mery, {Leslie S.} and Alex Ferenczy and Franco, {Eduardo L.}",
year = "2001",
language = "English (US)",
volume = "28",
pages = "694--700",
journal = "Sexually Transmitted Diseases",
issn = "0148-5717",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Oncogenic human papillomavirus infection and cervical lesions in aboriginal women of Nunavut, Canada

AU - Healey, Sylvia M.

AU - Aronson, Kristan J.

AU - Mao, Yang

AU - Schlecht, Nicolas F.

AU - Mery, Leslie S.

AU - Ferenczy, Alex

AU - Franco, Eduardo L.

PY - 2001

Y1 - 2001

N2 - Background: The high rate of cervical cancer among aboriginal women of northern Canada has prompted the search for more aggressive methods to augment Papanicolaou (Pap) screening in this population. Nearly all cervical cancers result from oncogenic human papillomavirus (HPV) infections. This has generated interest for incorporating HPV testing into the current screening program. Goals: To determine the prevalence of oncogenic HPVs in Nunavut, and to assess the association between HPV and squamous intraepithelial lesions (SIL). Study Design: A cross-sectional study was conducted on the Pap-screened populations in 19 communities of Nunavut, Canada. Liquid-based cytology was used to screen for SIL. HPV testing was performed using the Hybrid Capture II assay. Correlates of HPV infection and SIL were assessed by logistic regression with control for potential confounders. Results: In 1290 women ages 13 to 79 years, the prevalence rate was 26% for oncogenic HPV and 6.9% for SIL. The odds ratio for the association between HPV and SIL was 37.9 (95% CI, 17.7-80.8) after multivariate adjustment. This association increased markedly with increasing viral load. More than 90% of the women with squamous intraepithelial lesions had positive test results for HPV. More than 75% of the women who had positive test results for HPV but negative test results for SIL were younger than 30 years. Conclusion: The results of this study form the basis for further evaluation of the role that liquid-based cytology and HPV testing plays and will contribute to the strategy for cervical cancer prevention in Nunavut.

AB - Background: The high rate of cervical cancer among aboriginal women of northern Canada has prompted the search for more aggressive methods to augment Papanicolaou (Pap) screening in this population. Nearly all cervical cancers result from oncogenic human papillomavirus (HPV) infections. This has generated interest for incorporating HPV testing into the current screening program. Goals: To determine the prevalence of oncogenic HPVs in Nunavut, and to assess the association between HPV and squamous intraepithelial lesions (SIL). Study Design: A cross-sectional study was conducted on the Pap-screened populations in 19 communities of Nunavut, Canada. Liquid-based cytology was used to screen for SIL. HPV testing was performed using the Hybrid Capture II assay. Correlates of HPV infection and SIL were assessed by logistic regression with control for potential confounders. Results: In 1290 women ages 13 to 79 years, the prevalence rate was 26% for oncogenic HPV and 6.9% for SIL. The odds ratio for the association between HPV and SIL was 37.9 (95% CI, 17.7-80.8) after multivariate adjustment. This association increased markedly with increasing viral load. More than 90% of the women with squamous intraepithelial lesions had positive test results for HPV. More than 75% of the women who had positive test results for HPV but negative test results for SIL were younger than 30 years. Conclusion: The results of this study form the basis for further evaluation of the role that liquid-based cytology and HPV testing plays and will contribute to the strategy for cervical cancer prevention in Nunavut.

UR - http://www.scopus.com/inward/record.url?scp=0035209804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035209804&partnerID=8YFLogxK

M3 - Article

VL - 28

SP - 694

EP - 700

JO - Sexually Transmitted Diseases

JF - Sexually Transmitted Diseases

SN - 0148-5717

IS - 12

ER -