TY - JOUR
T1 - On voxel-by-voxel accumulated dose for prostate radiation therapy using deformable image registration
AU - Yu, Jialu
AU - Hardcastle, Nicholas
AU - Jeong, Kyoungkeun
AU - Bender, Edward T.
AU - Ritter, Mark A.
AU - Tomé, Wolfgang A.
N1 - Publisher Copyright:
© 2014 The Author(s).
PY - 2014
Y1 - 2014
N2 - Since delivered dose is rarely the same with planned, we calculated the delivered total dose to ten prostate radiotherapy patients treated with rectal balloons using deformable dose accumulation (DDA) and compared it with the planned dose. The patients were treated with TomoTherapy using two rectal balloon designs: five patients had the Radiadyne balloon (balloon A), and five patients had the EZ-EM balloon (balloon B). Prostate and rectal wall contours were outlined on each pre-treatment MVCT for all patients. Delivered fractional doses were calculated using the MVCT taken immediately prior to delivery. Dose grids were accumulated to the last MVCT using DDA tools in Pinnacle3 TM (v9.100, Philips Radiation Oncology Systems, Fitchburg, USA). Delivered total doses were compared with planned doses using prostate and rectal wall DVHs. The rectal NTCP was calculated based on total delivered and planned doses for all patients using the Lyman model. For 8/10 patients, the rectal wall NTCP calculated using the delivered total dose was less than planned, with seven patients showing a decrease of more than 5% in NTCP. For 2/10 patients studied, the rectal wall NTCP calculated using total delivered dose was 2% higher than planned. This study indicates that for patients receiving hypofractionated radiotherapy for prostate cancer with a rectal balloon, total delivered doses to prostate is similar with planned while delivered dose to rectal walls may be significantly different from planned doses. 8/10 patients show significant correlation between rectal balloon anterior-posterior positions and some VD values.
AB - Since delivered dose is rarely the same with planned, we calculated the delivered total dose to ten prostate radiotherapy patients treated with rectal balloons using deformable dose accumulation (DDA) and compared it with the planned dose. The patients were treated with TomoTherapy using two rectal balloon designs: five patients had the Radiadyne balloon (balloon A), and five patients had the EZ-EM balloon (balloon B). Prostate and rectal wall contours were outlined on each pre-treatment MVCT for all patients. Delivered fractional doses were calculated using the MVCT taken immediately prior to delivery. Dose grids were accumulated to the last MVCT using DDA tools in Pinnacle3 TM (v9.100, Philips Radiation Oncology Systems, Fitchburg, USA). Delivered total doses were compared with planned doses using prostate and rectal wall DVHs. The rectal NTCP was calculated based on total delivered and planned doses for all patients using the Lyman model. For 8/10 patients, the rectal wall NTCP calculated using the delivered total dose was less than planned, with seven patients showing a decrease of more than 5% in NTCP. For 2/10 patients studied, the rectal wall NTCP calculated using total delivered dose was 2% higher than planned. This study indicates that for patients receiving hypofractionated radiotherapy for prostate cancer with a rectal balloon, total delivered doses to prostate is similar with planned while delivered dose to rectal walls may be significantly different from planned doses. 8/10 patients show significant correlation between rectal balloon anterior-posterior positions and some VD values.
KW - DIR
KW - Deformable dose accumulation
KW - Planned versus delivered NTCP
KW - Planned versus delivered TCP
KW - gEUD
UR - http://www.scopus.com/inward/record.url?scp=84922264270&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922264270&partnerID=8YFLogxK
U2 - 10.7785/tcrt.2012.500397
DO - 10.7785/tcrt.2012.500397
M3 - Article
C2 - 24354754
AN - SCOPUS:84922264270
SN - 1533-0346
VL - 14
SP - 37
EP - 47
JO - Technology in Cancer Research and Treatment
JF - Technology in Cancer Research and Treatment
IS - 1
ER -