(Equation Presented) The syntheses of two epothilone analogues, 15(S)-aza-12,13-desoxyepothilone B and the epimeric 15(R)-aza-12,13-desoxyepothilone B, are described. A Mitsunobu inversion was utilized for elaboration of pre-epothilone fragments to the corresponding macrolactam. Tubulin binding and cytotoxicity profiles of these analogues are presented.
|Original language||English (US)|
|Number of pages||3|
|Publication status||Published - Jun 1 2000|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry