On the theory of tumor self-seeding: Implications for metastasis progression in humans

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23 Scopus citations

Abstract

Metastasis remains the leading cause of death among cancer patients because few effective treatment options are available. A recent paper proposes a new twist on metastasis. The paper shows that circulating tumor cells can return to the primary tumor, a process termed tumor self-seeding or cross-seeding, and that this helps breeding tumor cells that give rise to aggressive metastatic variants. A viewpoint presented here addresses the implications of these studies for human cancer metastasis.

Original languageEnglish (US)
Article number304
JournalBreast Cancer Research
Volume12
Issue number2
DOIs
StatePublished - Apr 28 2010
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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