On the role of retrosplenial cortex in long-lasting memory storage

Cynthia Katche, Guido Dorman, Carolina Gonzalez, Cecilia P. Kramar, Leandro Slipczuk, Janine I. Rossato, Martin Cammarota, Jorge H. Medina

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement in memory processing is unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis and c-Fos expression in the anterior part of RSC (aRSC) are necessary late after training to maintain for many days a fear-motivated memory. Long-lasting memory storage is regulated by D1/D5 dopamine receptors in aRSC and depends on the functional interplay between dorsal hippocampus and aRSC. These results suggest that the RSC recapitulates some of the molecular events that occur in the hippocampus to maintain memory trace over time.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalHippocampus
Volume23
Issue number4
DOIs
StatePublished - Apr 2013

Keywords

  • C-Fos
  • Dopamine
  • Hippocampus
  • Memory persistence
  • Protein synthesis

ASJC Scopus subject areas

  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'On the role of retrosplenial cortex in long-lasting memory storage'. Together they form a unique fingerprint.

Cite this