On the occurrence and enigmatic functions of mixed (chemical plus electrical) synapses in the mammalian CNS

James I. Nagy, Alberto E. Pereda, John E. Rash

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Electrical synapses with diverse configurations and functions occur at a variety of interneuronal appositions, thereby significantly expanding the physiological complexity of neuronal circuitry over that provided solely by chemical synapses. Gap junctions between apposed dendritic and somatic plasma membranes form "purely electrical" synapses that allow for electrical communication between coupled neurons. In addition, gap junctions at axon terminals synapsing on dendrites and somata allow for "mixed" (dual chemical + electrical) synaptic transmission. "Dual transmission" was first documented in the autonomic nervous system of birds, followed by its detection in the central nervous systems of fish, amphibia, and reptiles. Subsequently, mixed synapses have been detected in several locations in the mammalian CNS, where their properties and functional roles remain undetermined. Here, we review available evidence for the presence, complex structural composition, and emerging functional properties of mixed synapses in the mammalian CNS.

Original languageEnglish (US)
JournalNeuroscience Letters
DOIs
StateAccepted/In press - 2017

Fingerprint

Electrical Synapses
Synapses
Gap Junctions
Reptiles
Autonomic Nervous System
Presynaptic Terminals
Carisoprodol
Amphibians
Dendrites
Synaptic Transmission
Birds
Fishes
Central Nervous System
Communication
Cell Membrane
Neurons

Keywords

  • Connexins
  • Dye coupling
  • Electrical coupling
  • Nerve terminals
  • Neuronal gap junctions

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{f4f3bc0efbfa46238531df78ecfa6712,
title = "On the occurrence and enigmatic functions of mixed (chemical plus electrical) synapses in the mammalian CNS",
abstract = "Electrical synapses with diverse configurations and functions occur at a variety of interneuronal appositions, thereby significantly expanding the physiological complexity of neuronal circuitry over that provided solely by chemical synapses. Gap junctions between apposed dendritic and somatic plasma membranes form {"}purely electrical{"} synapses that allow for electrical communication between coupled neurons. In addition, gap junctions at axon terminals synapsing on dendrites and somata allow for {"}mixed{"} (dual chemical + electrical) synaptic transmission. {"}Dual transmission{"} was first documented in the autonomic nervous system of birds, followed by its detection in the central nervous systems of fish, amphibia, and reptiles. Subsequently, mixed synapses have been detected in several locations in the mammalian CNS, where their properties and functional roles remain undetermined. Here, we review available evidence for the presence, complex structural composition, and emerging functional properties of mixed synapses in the mammalian CNS.",
keywords = "Connexins, Dye coupling, Electrical coupling, Nerve terminals, Neuronal gap junctions",
author = "Nagy, {James I.} and Pereda, {Alberto E.} and Rash, {John E.}",
year = "2017",
doi = "10.1016/j.neulet.2017.09.021",
language = "English (US)",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - On the occurrence and enigmatic functions of mixed (chemical plus electrical) synapses in the mammalian CNS

AU - Nagy, James I.

AU - Pereda, Alberto E.

AU - Rash, John E.

PY - 2017

Y1 - 2017

N2 - Electrical synapses with diverse configurations and functions occur at a variety of interneuronal appositions, thereby significantly expanding the physiological complexity of neuronal circuitry over that provided solely by chemical synapses. Gap junctions between apposed dendritic and somatic plasma membranes form "purely electrical" synapses that allow for electrical communication between coupled neurons. In addition, gap junctions at axon terminals synapsing on dendrites and somata allow for "mixed" (dual chemical + electrical) synaptic transmission. "Dual transmission" was first documented in the autonomic nervous system of birds, followed by its detection in the central nervous systems of fish, amphibia, and reptiles. Subsequently, mixed synapses have been detected in several locations in the mammalian CNS, where their properties and functional roles remain undetermined. Here, we review available evidence for the presence, complex structural composition, and emerging functional properties of mixed synapses in the mammalian CNS.

AB - Electrical synapses with diverse configurations and functions occur at a variety of interneuronal appositions, thereby significantly expanding the physiological complexity of neuronal circuitry over that provided solely by chemical synapses. Gap junctions between apposed dendritic and somatic plasma membranes form "purely electrical" synapses that allow for electrical communication between coupled neurons. In addition, gap junctions at axon terminals synapsing on dendrites and somata allow for "mixed" (dual chemical + electrical) synaptic transmission. "Dual transmission" was first documented in the autonomic nervous system of birds, followed by its detection in the central nervous systems of fish, amphibia, and reptiles. Subsequently, mixed synapses have been detected in several locations in the mammalian CNS, where their properties and functional roles remain undetermined. Here, we review available evidence for the presence, complex structural composition, and emerging functional properties of mixed synapses in the mammalian CNS.

KW - Connexins

KW - Dye coupling

KW - Electrical coupling

KW - Nerve terminals

KW - Neuronal gap junctions

UR - http://www.scopus.com/inward/record.url?scp=85029558864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029558864&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2017.09.021

DO - 10.1016/j.neulet.2017.09.021

M3 - Article

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -