On the inclusion of proliferation in tumour control probability calculations for inhomogeneously irradiated tumours

Wolfgang A. Tomé, Jack F. Fowler

Research output: Contribution to journalArticle

18 Scopus citations


In previous modelling of tumour control probability (TCP) for inhomogeneously irradiated tumours we used an expression that did not include a proliferation correction term, which should be λ (T - Tk). We did not use that term in the specific examples in our previous work to model slowly growing tumours in order to avoid unnecessary mathematical complexity. We have now considered how to do so in more detail, and there are some variations, such as schedules that depart from a number of equal fractions over the entire course of treatment, if one wishes to compensate for proliferation in the remaining fractions by increasing the dose per fraction after the kick-off time has passed in order to achieve the same TCP when proliferation is neglected.

Original languageEnglish (US)
Pages (from-to)N261-N268
JournalPhysics in Medicine and Biology
Issue number18
Publication statusPublished - Sep 21 2003
Externally publishedYes


ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this