On the expression of H-Y antigen in transsexuals

Stephen Wachtel, Richard Green, Neal G. Simon, Alison Reichart, Linda Theill Cahill, John Hall, Dean Nakamura, Gwendolyn Wachtel, Walter Futterweit, Stanley H. Biber, Charles Ihlenfeld

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Histocompatibility-Y (H-Y) antigen, the presumptive inducer of the mammalian testis, is present in the cells of normal males and not in the cells of normal females. Recent reports have implied that patients with transsexualism exhibit H-Y antigen phenotypes at variance with those of normal males and females and, thus, that H-Y serology might provide a tool for the diagnosis and study of the transsexual condition. We therefore evaluated blood and testicular cells from 21 male-to-female transsexuals using conventional and monoclonal H-Y antibodies. We found no evidence of abnormal H-Y phenotype. Five of the patients were interviewed postoperatively by two examiners and rated for the diagnosis of transsexualism. Three of the five were rated primary transsexual by one or both examiners, and two were rated secondary transsexual.

Original languageEnglish (US)
Pages (from-to)51-68
Number of pages18
JournalArchives of Sexual Behavior
Volume15
Issue number1
DOIs
StatePublished - Feb 1 1986
Externally publishedYes

Fingerprint

Histocompatibility Antigens
Histocompatibility
Transsexualism
Phenotype
Serology
Testis
Blood Cells
Antibodies
Transsexual
Cells

Keywords

  • H-Y antigen
  • psychosexual differentiation
  • sexual identity
  • transsexual

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychology(all)

Cite this

Wachtel, S., Green, R., Simon, N. G., Reichart, A., Cahill, L. T., Hall, J., ... Ihlenfeld, C. (1986). On the expression of H-Y antigen in transsexuals. Archives of Sexual Behavior, 15(1), 51-68. https://doi.org/10.1007/BF01542304

On the expression of H-Y antigen in transsexuals. / Wachtel, Stephen; Green, Richard; Simon, Neal G.; Reichart, Alison; Cahill, Linda Theill; Hall, John; Nakamura, Dean; Wachtel, Gwendolyn; Futterweit, Walter; Biber, Stanley H.; Ihlenfeld, Charles.

In: Archives of Sexual Behavior, Vol. 15, No. 1, 01.02.1986, p. 51-68.

Research output: Contribution to journalArticle

Wachtel, S, Green, R, Simon, NG, Reichart, A, Cahill, LT, Hall, J, Nakamura, D, Wachtel, G, Futterweit, W, Biber, SH & Ihlenfeld, C 1986, 'On the expression of H-Y antigen in transsexuals', Archives of Sexual Behavior, vol. 15, no. 1, pp. 51-68. https://doi.org/10.1007/BF01542304
Wachtel S, Green R, Simon NG, Reichart A, Cahill LT, Hall J et al. On the expression of H-Y antigen in transsexuals. Archives of Sexual Behavior. 1986 Feb 1;15(1):51-68. https://doi.org/10.1007/BF01542304
Wachtel, Stephen ; Green, Richard ; Simon, Neal G. ; Reichart, Alison ; Cahill, Linda Theill ; Hall, John ; Nakamura, Dean ; Wachtel, Gwendolyn ; Futterweit, Walter ; Biber, Stanley H. ; Ihlenfeld, Charles. / On the expression of H-Y antigen in transsexuals. In: Archives of Sexual Behavior. 1986 ; Vol. 15, No. 1. pp. 51-68.
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