In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.
|Original language||English (US)|
|Number of pages||8|
|State||Published - May 20 2010|
- Olfactory bulbectomy
- Oxidative stress
ASJC Scopus subject areas