Olfactory bulbectomy induced oxidative and cell damage in rat

Protective effect of melatonin

Inmaculada Tasset, F. J. Medina, J. Peña, I. Jimena, M. del Carmen muñoz, M. Salcedo, C. Ruiz, M. Feijóo, P. Montilla, I. Túnez

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalPhysiological Research
Volume59
Issue number1
StatePublished - 2010
Externally publishedYes

Fingerprint

Melatonin
Caspase 3
Lipid Peroxidation
Glutathione
Oxidative Stress
Enzymes

Keywords

  • Antioxidant
  • Depression
  • Melatonin
  • Olfactory bulbectomy
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology

Cite this

Tasset, I., Medina, F. J., Peña, J., Jimena, I., muñoz, M. D. C., Salcedo, M., ... Túnez, I. (2010). Olfactory bulbectomy induced oxidative and cell damage in rat: Protective effect of melatonin. Physiological Research, 59(1), 105-112.

Olfactory bulbectomy induced oxidative and cell damage in rat : Protective effect of melatonin. / Tasset, Inmaculada; Medina, F. J.; Peña, J.; Jimena, I.; muñoz, M. del Carmen; Salcedo, M.; Ruiz, C.; Feijóo, M.; Montilla, P.; Túnez, I.

In: Physiological Research, Vol. 59, No. 1, 2010, p. 105-112.

Research output: Contribution to journalArticle

Tasset, I, Medina, FJ, Peña, J, Jimena, I, muñoz, MDC, Salcedo, M, Ruiz, C, Feijóo, M, Montilla, P & Túnez, I 2010, 'Olfactory bulbectomy induced oxidative and cell damage in rat: Protective effect of melatonin', Physiological Research, vol. 59, no. 1, pp. 105-112.
Tasset I, Medina FJ, Peña J, Jimena I, muñoz MDC, Salcedo M et al. Olfactory bulbectomy induced oxidative and cell damage in rat: Protective effect of melatonin. Physiological Research. 2010;59(1):105-112.
Tasset, Inmaculada ; Medina, F. J. ; Peña, J. ; Jimena, I. ; muñoz, M. del Carmen ; Salcedo, M. ; Ruiz, C. ; Feijóo, M. ; Montilla, P. ; Túnez, I. / Olfactory bulbectomy induced oxidative and cell damage in rat : Protective effect of melatonin. In: Physiological Research. 2010 ; Vol. 59, No. 1. pp. 105-112.
@article{63c3558144c840a0832951708512a631,
title = "Olfactory bulbectomy induced oxidative and cell damage in rat: Protective effect of melatonin",
abstract = "In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.",
keywords = "Antioxidant, Depression, Melatonin, Olfactory bulbectomy, Oxidative stress",
author = "Inmaculada Tasset and Medina, {F. J.} and J. Pe{\~n}a and I. Jimena and mu{\~n}oz, {M. del Carmen} and M. Salcedo and C. Ruiz and M. Feij{\'o}o and P. Montilla and I. T{\'u}nez",
year = "2010",
language = "English (US)",
volume = "59",
pages = "105--112",
journal = "Physiological Research",
issn = "0862-8408",
publisher = "Czech Academy of Sciences",
number = "1",

}

TY - JOUR

T1 - Olfactory bulbectomy induced oxidative and cell damage in rat

T2 - Protective effect of melatonin

AU - Tasset, Inmaculada

AU - Medina, F. J.

AU - Peña, J.

AU - Jimena, I.

AU - muñoz, M. del Carmen

AU - Salcedo, M.

AU - Ruiz, C.

AU - Feijóo, M.

AU - Montilla, P.

AU - Túnez, I.

PY - 2010

Y1 - 2010

N2 - In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.

AB - In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.

KW - Antioxidant

KW - Depression

KW - Melatonin

KW - Olfactory bulbectomy

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=77952294995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952294995&partnerID=8YFLogxK

M3 - Article

VL - 59

SP - 105

EP - 112

JO - Physiological Research

JF - Physiological Research

SN - 0862-8408

IS - 1

ER -