Olfactory bulbectomy induced oxidative and cell damage in rat: Protective effect of melatonin

I. Tasset, F. J. Medina, J. Peña, I. Jimena, M. del Carmen muñoz, M. Salcedo, C. Ruiz, M. Feijóo, P. Montilla, I. Túnez

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalPhysiological Research
Volume59
Issue number1
StatePublished - May 20 2010
Externally publishedYes

Keywords

  • Antioxidant
  • Depression
  • Melatonin
  • Olfactory bulbectomy
  • Oxidative stress

ASJC Scopus subject areas

  • Physiology

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