Oleic acid directly regulates POMC neuron excitability in the hypothalamus

Young-Hwan Jo, Ya Su, Roger Gutierrez-Juarez, Streamson C. Chua, Jr.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The mammalian CNS relies on a constant supply of external glucose for its undisturbed operation. However, neurons can readily switch to using fatty acids and ketones as alternative fuels. Here, we show that oleic acid (OA) excites pro-opiomelanocortin (POMC) neurons by inhibition of ATP-activated potassium (KATP) channels. The involvement of KATP channels is further supported by experiments in SUR1 KO animals. Inhibition of β-oxidation using carnitine palmitoyltransferase-1 inhibitors blocks OA-induced depolarization. The depolarizing effect of OA is specific because it is not mimicked by octanoic acid. Furthermore, OA does not regulate the excitability of agouti-related peptide neurons. High-fat feeding alters POMC neuron excitability, but not its response to OA. Thus β-oxidation in POMC neurons may mediate the appetite-suppressing (anorexigenic) effects of OA.

Original languageEnglish (US)
Pages (from-to)2305-2316
Number of pages12
JournalJournal of Neurophysiology
Volume101
Issue number5
DOIs
StatePublished - May 2009

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Pro-Opiomelanocortin
Oleic Acid
Hypothalamus
Neurons
KATP Channels
Carnitine O-Palmitoyltransferase
Potassium Channels
Appetite
Ketones
Fatty Acids
Adenosine Triphosphate
Fats
Glucose
Peptides

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Oleic acid directly regulates POMC neuron excitability in the hypothalamus. / Jo, Young-Hwan; Su, Ya; Gutierrez-Juarez, Roger; Chua, Jr., Streamson C.

In: Journal of Neurophysiology, Vol. 101, No. 5, 05.2009, p. 2305-2316.

Research output: Contribution to journalArticle

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