Older patients are significantly more likely to have colon ischaemia-associated conditions that are chronic and complex

Michael Silverman, Olga C. Aroniadis, Paul Feuerstadt, Marc Fenster, Tsipora Huisman, Muhammad Sohail Mansoor, Abdul Qadir Bhutta, Lawrence J. Brandt

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Colon ischaemia is a common disease which has been associated with various medications and comorbidities. Aim: To test the hypothesis that there are differences in the frequencies of these associations in older compared with younger patients. Methods: A retrospective cohort study was performed of patients hospitalized with colon ischaemia at two major medical centres from 2005-2017. Clinical, colonoscopic and pathologic criteria were used to identify patients admitted with colon ischaemia; patients with other types of colitis were excluded. Demographic and medical data were extracted. Two cohorts were created: patients aged 18-64 years and patients > 65 years. These were compared using SAS 14.3. Results: A total of 788 patients were included, of which 271 (34.4%) were of ages 18-64 years, and 517 (66.6%) were 65 years old or older. In the older cohort, constipation-inducing medications (83.8% vs 64.1%; P = <0.0001), diuretics (38.1% vs 25.1%; P = <0.001) and nonsteroidal anti-inflammatory drugs (58% vs 41.5%; P = <0.0001) were more common than in the younger cohort. Antipsychotic medication use was more common in the younger cohort (10.4% vs 5.4%; P = 0.01). There was a higher percentage of younger patients with a history of hypercoaguable state (1.9% vs 0.2%; P = 0.03) and dialysis dependence (22.9% vs 8.7%; P = <0.01), while a higher percentage of patients in the older cohort had a history of chronic obstructive pulmonary disease (12% vs 6.3%; P = 0.01) or atrial fibrillation (18.9% vs 10.3%; P = <0.01). Conclusions: Our study shows that older patients are more likely to have colon ischaemia-associated conditions that are chronic and complex, while younger patients are more likely to have acute colon ischaemia-associated conditions.

Original languageEnglish (US)
JournalAlimentary Pharmacology and Therapeutics
DOIs
StatePublished - Jan 1 2019

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Colon
Ischemia
Constipation
Colitis
Diuretics
Atrial Fibrillation
Chronic Obstructive Pulmonary Disease
Antipsychotic Agents
Comorbidity
Dialysis
Cohort Studies
Anti-Inflammatory Agents
Retrospective Studies
Demography
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

Cite this

Older patients are significantly more likely to have colon ischaemia-associated conditions that are chronic and complex. / Silverman, Michael; Aroniadis, Olga C.; Feuerstadt, Paul; Fenster, Marc; Huisman, Tsipora; Mansoor, Muhammad Sohail; Bhutta, Abdul Qadir; Brandt, Lawrence J.

In: Alimentary Pharmacology and Therapeutics, 01.01.2019.

Research output: Contribution to journalArticle

Silverman, Michael ; Aroniadis, Olga C. ; Feuerstadt, Paul ; Fenster, Marc ; Huisman, Tsipora ; Mansoor, Muhammad Sohail ; Bhutta, Abdul Qadir ; Brandt, Lawrence J. / Older patients are significantly more likely to have colon ischaemia-associated conditions that are chronic and complex. In: Alimentary Pharmacology and Therapeutics. 2019.
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abstract = "Background: Colon ischaemia is a common disease which has been associated with various medications and comorbidities. Aim: To test the hypothesis that there are differences in the frequencies of these associations in older compared with younger patients. Methods: A retrospective cohort study was performed of patients hospitalized with colon ischaemia at two major medical centres from 2005-2017. Clinical, colonoscopic and pathologic criteria were used to identify patients admitted with colon ischaemia; patients with other types of colitis were excluded. Demographic and medical data were extracted. Two cohorts were created: patients aged 18-64 years and patients > 65 years. These were compared using SAS 14.3. Results: A total of 788 patients were included, of which 271 (34.4{\%}) were of ages 18-64 years, and 517 (66.6{\%}) were 65 years old or older. In the older cohort, constipation-inducing medications (83.8{\%} vs 64.1{\%}; P = <0.0001), diuretics (38.1{\%} vs 25.1{\%}; P = <0.001) and nonsteroidal anti-inflammatory drugs (58{\%} vs 41.5{\%}; P = <0.0001) were more common than in the younger cohort. Antipsychotic medication use was more common in the younger cohort (10.4{\%} vs 5.4{\%}; P = 0.01). There was a higher percentage of younger patients with a history of hypercoaguable state (1.9{\%} vs 0.2{\%}; P = 0.03) and dialysis dependence (22.9{\%} vs 8.7{\%}; P = <0.01), while a higher percentage of patients in the older cohort had a history of chronic obstructive pulmonary disease (12{\%} vs 6.3{\%}; P = 0.01) or atrial fibrillation (18.9{\%} vs 10.3{\%}; P = <0.01). Conclusions: Our study shows that older patients are more likely to have colon ischaemia-associated conditions that are chronic and complex, while younger patients are more likely to have acute colon ischaemia-associated conditions.",
author = "Michael Silverman and Aroniadis, {Olga C.} and Paul Feuerstadt and Marc Fenster and Tsipora Huisman and Mansoor, {Muhammad Sohail} and Bhutta, {Abdul Qadir} and Brandt, {Lawrence J.}",
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T1 - Older patients are significantly more likely to have colon ischaemia-associated conditions that are chronic and complex

AU - Silverman, Michael

AU - Aroniadis, Olga C.

AU - Feuerstadt, Paul

AU - Fenster, Marc

AU - Huisman, Tsipora

AU - Mansoor, Muhammad Sohail

AU - Bhutta, Abdul Qadir

AU - Brandt, Lawrence J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Colon ischaemia is a common disease which has been associated with various medications and comorbidities. Aim: To test the hypothesis that there are differences in the frequencies of these associations in older compared with younger patients. Methods: A retrospective cohort study was performed of patients hospitalized with colon ischaemia at two major medical centres from 2005-2017. Clinical, colonoscopic and pathologic criteria were used to identify patients admitted with colon ischaemia; patients with other types of colitis were excluded. Demographic and medical data were extracted. Two cohorts were created: patients aged 18-64 years and patients > 65 years. These were compared using SAS 14.3. Results: A total of 788 patients were included, of which 271 (34.4%) were of ages 18-64 years, and 517 (66.6%) were 65 years old or older. In the older cohort, constipation-inducing medications (83.8% vs 64.1%; P = <0.0001), diuretics (38.1% vs 25.1%; P = <0.001) and nonsteroidal anti-inflammatory drugs (58% vs 41.5%; P = <0.0001) were more common than in the younger cohort. Antipsychotic medication use was more common in the younger cohort (10.4% vs 5.4%; P = 0.01). There was a higher percentage of younger patients with a history of hypercoaguable state (1.9% vs 0.2%; P = 0.03) and dialysis dependence (22.9% vs 8.7%; P = <0.01), while a higher percentage of patients in the older cohort had a history of chronic obstructive pulmonary disease (12% vs 6.3%; P = 0.01) or atrial fibrillation (18.9% vs 10.3%; P = <0.01). Conclusions: Our study shows that older patients are more likely to have colon ischaemia-associated conditions that are chronic and complex, while younger patients are more likely to have acute colon ischaemia-associated conditions.

AB - Background: Colon ischaemia is a common disease which has been associated with various medications and comorbidities. Aim: To test the hypothesis that there are differences in the frequencies of these associations in older compared with younger patients. Methods: A retrospective cohort study was performed of patients hospitalized with colon ischaemia at two major medical centres from 2005-2017. Clinical, colonoscopic and pathologic criteria were used to identify patients admitted with colon ischaemia; patients with other types of colitis were excluded. Demographic and medical data were extracted. Two cohorts were created: patients aged 18-64 years and patients > 65 years. These were compared using SAS 14.3. Results: A total of 788 patients were included, of which 271 (34.4%) were of ages 18-64 years, and 517 (66.6%) were 65 years old or older. In the older cohort, constipation-inducing medications (83.8% vs 64.1%; P = <0.0001), diuretics (38.1% vs 25.1%; P = <0.001) and nonsteroidal anti-inflammatory drugs (58% vs 41.5%; P = <0.0001) were more common than in the younger cohort. Antipsychotic medication use was more common in the younger cohort (10.4% vs 5.4%; P = 0.01). There was a higher percentage of younger patients with a history of hypercoaguable state (1.9% vs 0.2%; P = 0.03) and dialysis dependence (22.9% vs 8.7%; P = <0.01), while a higher percentage of patients in the older cohort had a history of chronic obstructive pulmonary disease (12% vs 6.3%; P = 0.01) or atrial fibrillation (18.9% vs 10.3%; P = <0.01). Conclusions: Our study shows that older patients are more likely to have colon ischaemia-associated conditions that are chronic and complex, while younger patients are more likely to have acute colon ischaemia-associated conditions.

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