Old microbes with new faces: molecular biology and the design of new vaccines

Nancy Connell, C. Kenneth Stover, William R. Jacobs

Research output: Contribution to journalArticle

8 Scopus citations


Rational approaches to the design of live attenuated bacterial and viral recombinant vaccine strains are leading to the manipulation of old vaccines and the generation of new ones. The two basic problems to be solved are attenuation of pathogenic strains, and the stable expression of foreign.

Original languageEnglish (US)
Pages (from-to)442-448
Number of pages7
JournalCurrent Opinion in Immunology
Issue number4
Publication statusPublished - 1992


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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