Abstract
Rational approaches to the design of live attenuated bacterial and viral recombinant vaccine strains are leading to the manipulation of old vaccines and the generation of new ones. The two basic problems to be solved are attenuation of pathogenic strains, and the stable expression of foreign.
Original language | English (US) |
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Pages (from-to) | 442-448 |
Number of pages | 7 |
Journal | Current Opinion in Immunology |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - 1992 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology