OK-432 and IL-2-augmental cytotoxicity of human natural killer cells and cytotoxic T lymphocytes at the clonal level

Claudia Gravekamp, Rea Vreugdenhil, Reinder L H Bolhuis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The biology response modifiers OK-432 and interleukin-2 (IL-2) were found to enhance the lytic capacity of cloned CD3- natural killer (NK) cells and CD3+ T cells. With respect to NK cells, only those clones with a high proliferative capacity and cultured without phytohaemagglutinin (PHA) responded with enhaced lytic capacity to OK-432. OK-432, but not IL-2, was found to augment the antibody-dependent cellular cytotoxicity of cloned NK cells. With T-cell clones, OK-432 augmented the cellular cytotoxicity of CD3+8+ but not that of CD3+4+ cytotoxic T lymphocytes, while IL-2 augmented the cytotoxicity of both types of clone. Taken together, these results indicate that OK-432-augmented lytic capacity is not restricted to NK cells and its pathway of action may be independent of IL-2.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
JournalFEMS Microbiology Letters
Volume47
Issue number1
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Picibanil
Cytotoxic T-Lymphocytes
Natural Killer Cells
Interleukin-2
Clone Cells
T-Lymphocytes
Phytohemagglutinins
Antibodies

Keywords

  • Antibody-dependent cellular cytotoxicity
  • Biological response modifer
  • Cytotoxic T lymphocyte
  • Natural killer cell
  • Streptococcus pyogenes

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

OK-432 and IL-2-augmental cytotoxicity of human natural killer cells and cytotoxic T lymphocytes at the clonal level. / Gravekamp, Claudia; Vreugdenhil, Rea; Bolhuis, Reinder L H.

In: FEMS Microbiology Letters, Vol. 47, No. 1, 1988, p. 31-39.

Research output: Contribution to journalArticle

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N2 - The biology response modifiers OK-432 and interleukin-2 (IL-2) were found to enhance the lytic capacity of cloned CD3- natural killer (NK) cells and CD3+ T cells. With respect to NK cells, only those clones with a high proliferative capacity and cultured without phytohaemagglutinin (PHA) responded with enhaced lytic capacity to OK-432. OK-432, but not IL-2, was found to augment the antibody-dependent cellular cytotoxicity of cloned NK cells. With T-cell clones, OK-432 augmented the cellular cytotoxicity of CD3+8+ but not that of CD3+4+ cytotoxic T lymphocytes, while IL-2 augmented the cytotoxicity of both types of clone. Taken together, these results indicate that OK-432-augmented lytic capacity is not restricted to NK cells and its pathway of action may be independent of IL-2.

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