Offspring of centenarians have a favorable lipid profile

Nir Barzilai, Ilan Gabriely, Magda Gabriely, Nancy Iankowitz, John D. Sorkin

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

OBJECTIVES: It is well recognized that a favorable lipid profile provides protection from atherosclerotic cardiovascular disease. Because the major cause of nontraumatic death in the western world is considered to be due to cardiovascular disease, centenarians (defined here as subjects over 95 years of age) are believed to possess "atherosclerotic protective" factors. However, it is impossible to study comparatively the lipid profile in centenarians because of lack of controls. Assuming that certain genes responsible for encoding the lipid phenotype may be inherited, we studied the lipid profile characteristics of offspring of centenarians and compared them with control groups. DESIGN: Prospective cohort study. SETTING: The study was part of the Longevity Genes Project at Albert Einstein College of Medicine. PARTICIPANTS: Ashkenazi Jewish centenarians (n = 27, 98.4 ± 10.4 years) and their offspring (n = 33, 67.4 ± 1.4 years). The Ashkenazi Jewish offsprings' spouses, who were not related by blood to the centenarians or their offspring, were used as a control group (n = 26, 68.4 ± 1.2 years). MEASUREMENTS: The lipoprotein profile of the offspring was compared with the above control group and to a larger control group (age and gender matched) from the National Health and Nutrition Examination Survey (NHANES) III study (without the sample weights, n = 394, 60 to 69 years). RESULTS: Female offspring of centenarians had significantly higher plasma levels of high density lipoproteincholesterol (HDL-C) levels compared with controls (70.2 ± 3.1 vs 59.0 ± 4.1 mg/dl, P = .029). Male offspring of centenarians had higher plasma levels of HDL-C levels (56.2 ± 7.1 vs 44.3 ± 3.4 mg/dl, P = 0.130) and significantly lower LDL-cholesterol (LDL-C) levels (95.0 ± 6.0 vs 127.0 ± 8.0 mg/dl, P = .009) compared with controls. CONCLUSION: Offspring of centenarians have a favorable lipid profile compared with controls. These data support the notion that a certain phenotypic lipid profile may be transmitted in families and suggest that a favorable lipid profile may play a role in longevity.

Original languageEnglish (US)
Pages (from-to)76-79
Number of pages4
JournalJournal of the American Geriatrics Society
Volume49
Issue number1
DOIs
StatePublished - 2001

Fingerprint

Lipids
Control Groups
Cardiovascular Diseases
Western World
Nutrition Surveys
Spouses
LDL Cholesterol
Genes
Lipoproteins
Cause of Death
Cohort Studies
Medicine
Prospective Studies
Phenotype
Weights and Measures

Keywords

  • Centenarians
  • Lipid profile
  • Longevity
  • Offspring

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Offspring of centenarians have a favorable lipid profile. / Barzilai, Nir; Gabriely, Ilan; Gabriely, Magda; Iankowitz, Nancy; Sorkin, John D.

In: Journal of the American Geriatrics Society, Vol. 49, No. 1, 2001, p. 76-79.

Research output: Contribution to journalArticle

Barzilai, Nir ; Gabriely, Ilan ; Gabriely, Magda ; Iankowitz, Nancy ; Sorkin, John D. / Offspring of centenarians have a favorable lipid profile. In: Journal of the American Geriatrics Society. 2001 ; Vol. 49, No. 1. pp. 76-79.
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AU - Barzilai, Nir

AU - Gabriely, Ilan

AU - Gabriely, Magda

AU - Iankowitz, Nancy

AU - Sorkin, John D.

PY - 2001

Y1 - 2001

N2 - OBJECTIVES: It is well recognized that a favorable lipid profile provides protection from atherosclerotic cardiovascular disease. Because the major cause of nontraumatic death in the western world is considered to be due to cardiovascular disease, centenarians (defined here as subjects over 95 years of age) are believed to possess "atherosclerotic protective" factors. However, it is impossible to study comparatively the lipid profile in centenarians because of lack of controls. Assuming that certain genes responsible for encoding the lipid phenotype may be inherited, we studied the lipid profile characteristics of offspring of centenarians and compared them with control groups. DESIGN: Prospective cohort study. SETTING: The study was part of the Longevity Genes Project at Albert Einstein College of Medicine. PARTICIPANTS: Ashkenazi Jewish centenarians (n = 27, 98.4 ± 10.4 years) and their offspring (n = 33, 67.4 ± 1.4 years). The Ashkenazi Jewish offsprings' spouses, who were not related by blood to the centenarians or their offspring, were used as a control group (n = 26, 68.4 ± 1.2 years). MEASUREMENTS: The lipoprotein profile of the offspring was compared with the above control group and to a larger control group (age and gender matched) from the National Health and Nutrition Examination Survey (NHANES) III study (without the sample weights, n = 394, 60 to 69 years). RESULTS: Female offspring of centenarians had significantly higher plasma levels of high density lipoproteincholesterol (HDL-C) levels compared with controls (70.2 ± 3.1 vs 59.0 ± 4.1 mg/dl, P = .029). Male offspring of centenarians had higher plasma levels of HDL-C levels (56.2 ± 7.1 vs 44.3 ± 3.4 mg/dl, P = 0.130) and significantly lower LDL-cholesterol (LDL-C) levels (95.0 ± 6.0 vs 127.0 ± 8.0 mg/dl, P = .009) compared with controls. CONCLUSION: Offspring of centenarians have a favorable lipid profile compared with controls. These data support the notion that a certain phenotypic lipid profile may be transmitted in families and suggest that a favorable lipid profile may play a role in longevity.

AB - OBJECTIVES: It is well recognized that a favorable lipid profile provides protection from atherosclerotic cardiovascular disease. Because the major cause of nontraumatic death in the western world is considered to be due to cardiovascular disease, centenarians (defined here as subjects over 95 years of age) are believed to possess "atherosclerotic protective" factors. However, it is impossible to study comparatively the lipid profile in centenarians because of lack of controls. Assuming that certain genes responsible for encoding the lipid phenotype may be inherited, we studied the lipid profile characteristics of offspring of centenarians and compared them with control groups. DESIGN: Prospective cohort study. SETTING: The study was part of the Longevity Genes Project at Albert Einstein College of Medicine. PARTICIPANTS: Ashkenazi Jewish centenarians (n = 27, 98.4 ± 10.4 years) and their offspring (n = 33, 67.4 ± 1.4 years). The Ashkenazi Jewish offsprings' spouses, who were not related by blood to the centenarians or their offspring, were used as a control group (n = 26, 68.4 ± 1.2 years). MEASUREMENTS: The lipoprotein profile of the offspring was compared with the above control group and to a larger control group (age and gender matched) from the National Health and Nutrition Examination Survey (NHANES) III study (without the sample weights, n = 394, 60 to 69 years). RESULTS: Female offspring of centenarians had significantly higher plasma levels of high density lipoproteincholesterol (HDL-C) levels compared with controls (70.2 ± 3.1 vs 59.0 ± 4.1 mg/dl, P = .029). Male offspring of centenarians had higher plasma levels of HDL-C levels (56.2 ± 7.1 vs 44.3 ± 3.4 mg/dl, P = 0.130) and significantly lower LDL-cholesterol (LDL-C) levels (95.0 ± 6.0 vs 127.0 ± 8.0 mg/dl, P = .009) compared with controls. CONCLUSION: Offspring of centenarians have a favorable lipid profile compared with controls. These data support the notion that a certain phenotypic lipid profile may be transmitted in families and suggest that a favorable lipid profile may play a role in longevity.

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