Occurrence of Adenovirus-SV40 Hybrids Among Monkey Kidney Cell Adapted Strains of Adenovirus

Andrew M. Lewis, Stephen G. Baum, Kirsten O. Prigge, Wallace P. Rowe

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The strains of adenovirus types 1 through 5 adapted to rhesus monkey kidney cultures for use in vaccines became contaminated with SV40 virus and formed hybrids, carrying SV40 genetic material in adenovirus capsids in a manner similar to that seen in Ad. 7 strain LLE46. The ability of the strains studied here to propagate in monkey cells (with the possible exception of type 5) is dependent on the SV40 genetic material and is not due to emergence of monkey-adapted adenovirus mutants.

Original languageEnglish (US)
Pages (from-to)214-218
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume122
Issue number1
DOIs
StatePublished - May 1966
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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