Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha

Bryan A. Bassig, Luoping Zhang, Xiaojiang Tang, Roel Vermeulen, Min Shen, Martyn T. Smith, Chuangyi Qiu, Yichen Ge, Zhiying Ji, Boris Reiss, Howard D. Hosgood, Songwang Liu, Rachel Bagni, Weihong Guo, Mark Purdue, Wei Hu, Fei Yue, Laiyu Li, Hanlin Huang, Nathaniel Rothman & 1 others Qing Lan

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To evaluate the immunotoxicity of trichloroethylene (TCE), we conducted a cross-sectional molecular epidemiology study in China of workers exposed to TCE. We measured serum levels of IL-6, IL-10, and TNF-α, which play a critical role in regulating various components of the immune system, in 71 exposed workers and 78 unexposed control workers. Repeated personal exposure measurements were taken in workers before blood collection using 3 M organic vapor monitoring badges. Compared to unexposed workers, the serum concentration of IL-10 in workers exposed to TCE was decreased by 70% (P=0.001) after adjusting for potential confounders. Further, the magnitude of decline in IL-10 was >60% and statistically significant in workers exposed to <12 ppm as well as in workers with exposures ≥ 12 ppm of TCE, compared to unexposed workers. No significant differences in levels of IL-6 or TNF-α were observed among workers exposed to TCE compared to unexposed controls. Given that IL-10 plays an important role in immunologic processes, including mediating the Th1/Th2 balance, our findings provide additional evidence that TCE is immunotoxic in humans.

Original languageEnglish (US)
Pages (from-to)450-454
Number of pages5
JournalEnvironmental and Molecular Mutagenesis
Volume54
Issue number6
DOIs
StatePublished - Jul 2013

Fingerprint

Trichloroethylene
Occupational Exposure
Interleukin-10
Interleukin-6
Tumor Necrosis Factor-alpha
Serum
Th1-Th2 Balance
Molecular Epidemiology
Immune System
China

Keywords

  • IL-10
  • IL-6
  • Immunotoxicity
  • Occupational exposure
  • TNF-α
  • Trichloroethylene

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Epidemiology
  • Genetics(clinical)

Cite this

Bassig, B. A., Zhang, L., Tang, X., Vermeulen, R., Shen, M., Smith, M. T., ... Lan, Q. (2013). Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha. Environmental and Molecular Mutagenesis, 54(6), 450-454. https://doi.org/10.1002/em.21789

Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha. / Bassig, Bryan A.; Zhang, Luoping; Tang, Xiaojiang; Vermeulen, Roel; Shen, Min; Smith, Martyn T.; Qiu, Chuangyi; Ge, Yichen; Ji, Zhiying; Reiss, Boris; Hosgood, Howard D.; Liu, Songwang; Bagni, Rachel; Guo, Weihong; Purdue, Mark; Hu, Wei; Yue, Fei; Li, Laiyu; Huang, Hanlin; Rothman, Nathaniel; Lan, Qing.

In: Environmental and Molecular Mutagenesis, Vol. 54, No. 6, 07.2013, p. 450-454.

Research output: Contribution to journalArticle

Bassig, BA, Zhang, L, Tang, X, Vermeulen, R, Shen, M, Smith, MT, Qiu, C, Ge, Y, Ji, Z, Reiss, B, Hosgood, HD, Liu, S, Bagni, R, Guo, W, Purdue, M, Hu, W, Yue, F, Li, L, Huang, H, Rothman, N & Lan, Q 2013, 'Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha', Environmental and Molecular Mutagenesis, vol. 54, no. 6, pp. 450-454. https://doi.org/10.1002/em.21789
Bassig, Bryan A. ; Zhang, Luoping ; Tang, Xiaojiang ; Vermeulen, Roel ; Shen, Min ; Smith, Martyn T. ; Qiu, Chuangyi ; Ge, Yichen ; Ji, Zhiying ; Reiss, Boris ; Hosgood, Howard D. ; Liu, Songwang ; Bagni, Rachel ; Guo, Weihong ; Purdue, Mark ; Hu, Wei ; Yue, Fei ; Li, Laiyu ; Huang, Hanlin ; Rothman, Nathaniel ; Lan, Qing. / Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha. In: Environmental and Molecular Mutagenesis. 2013 ; Vol. 54, No. 6. pp. 450-454.
@article{62d638882d4d4829a1fb4009c983506b,
title = "Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha",
abstract = "To evaluate the immunotoxicity of trichloroethylene (TCE), we conducted a cross-sectional molecular epidemiology study in China of workers exposed to TCE. We measured serum levels of IL-6, IL-10, and TNF-α, which play a critical role in regulating various components of the immune system, in 71 exposed workers and 78 unexposed control workers. Repeated personal exposure measurements were taken in workers before blood collection using 3 M organic vapor monitoring badges. Compared to unexposed workers, the serum concentration of IL-10 in workers exposed to TCE was decreased by 70{\%} (P=0.001) after adjusting for potential confounders. Further, the magnitude of decline in IL-10 was >60{\%} and statistically significant in workers exposed to <12 ppm as well as in workers with exposures ≥ 12 ppm of TCE, compared to unexposed workers. No significant differences in levels of IL-6 or TNF-α were observed among workers exposed to TCE compared to unexposed controls. Given that IL-10 plays an important role in immunologic processes, including mediating the Th1/Th2 balance, our findings provide additional evidence that TCE is immunotoxic in humans.",
keywords = "IL-10, IL-6, Immunotoxicity, Occupational exposure, TNF-α, Trichloroethylene",
author = "Bassig, {Bryan A.} and Luoping Zhang and Xiaojiang Tang and Roel Vermeulen and Min Shen and Smith, {Martyn T.} and Chuangyi Qiu and Yichen Ge and Zhiying Ji and Boris Reiss and Hosgood, {Howard D.} and Songwang Liu and Rachel Bagni and Weihong Guo and Mark Purdue and Wei Hu and Fei Yue and Laiyu Li and Hanlin Huang and Nathaniel Rothman and Qing Lan",
year = "2013",
month = "7",
doi = "10.1002/em.21789",
language = "English (US)",
volume = "54",
pages = "450--454",
journal = "Environmental and Molecular Mutagenesis",
issn = "0893-6692",
publisher = "Wiley-Liss Inc.",
number = "6",

}

TY - JOUR

T1 - Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha

AU - Bassig, Bryan A.

AU - Zhang, Luoping

AU - Tang, Xiaojiang

AU - Vermeulen, Roel

AU - Shen, Min

AU - Smith, Martyn T.

AU - Qiu, Chuangyi

AU - Ge, Yichen

AU - Ji, Zhiying

AU - Reiss, Boris

AU - Hosgood, Howard D.

AU - Liu, Songwang

AU - Bagni, Rachel

AU - Guo, Weihong

AU - Purdue, Mark

AU - Hu, Wei

AU - Yue, Fei

AU - Li, Laiyu

AU - Huang, Hanlin

AU - Rothman, Nathaniel

AU - Lan, Qing

PY - 2013/7

Y1 - 2013/7

N2 - To evaluate the immunotoxicity of trichloroethylene (TCE), we conducted a cross-sectional molecular epidemiology study in China of workers exposed to TCE. We measured serum levels of IL-6, IL-10, and TNF-α, which play a critical role in regulating various components of the immune system, in 71 exposed workers and 78 unexposed control workers. Repeated personal exposure measurements were taken in workers before blood collection using 3 M organic vapor monitoring badges. Compared to unexposed workers, the serum concentration of IL-10 in workers exposed to TCE was decreased by 70% (P=0.001) after adjusting for potential confounders. Further, the magnitude of decline in IL-10 was >60% and statistically significant in workers exposed to <12 ppm as well as in workers with exposures ≥ 12 ppm of TCE, compared to unexposed workers. No significant differences in levels of IL-6 or TNF-α were observed among workers exposed to TCE compared to unexposed controls. Given that IL-10 plays an important role in immunologic processes, including mediating the Th1/Th2 balance, our findings provide additional evidence that TCE is immunotoxic in humans.

AB - To evaluate the immunotoxicity of trichloroethylene (TCE), we conducted a cross-sectional molecular epidemiology study in China of workers exposed to TCE. We measured serum levels of IL-6, IL-10, and TNF-α, which play a critical role in regulating various components of the immune system, in 71 exposed workers and 78 unexposed control workers. Repeated personal exposure measurements were taken in workers before blood collection using 3 M organic vapor monitoring badges. Compared to unexposed workers, the serum concentration of IL-10 in workers exposed to TCE was decreased by 70% (P=0.001) after adjusting for potential confounders. Further, the magnitude of decline in IL-10 was >60% and statistically significant in workers exposed to <12 ppm as well as in workers with exposures ≥ 12 ppm of TCE, compared to unexposed workers. No significant differences in levels of IL-6 or TNF-α were observed among workers exposed to TCE compared to unexposed controls. Given that IL-10 plays an important role in immunologic processes, including mediating the Th1/Th2 balance, our findings provide additional evidence that TCE is immunotoxic in humans.

KW - IL-10

KW - IL-6

KW - Immunotoxicity

KW - Occupational exposure

KW - TNF-α

KW - Trichloroethylene

UR - http://www.scopus.com/inward/record.url?scp=84880045770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880045770&partnerID=8YFLogxK

U2 - 10.1002/em.21789

DO - 10.1002/em.21789

M3 - Article

VL - 54

SP - 450

EP - 454

JO - Environmental and Molecular Mutagenesis

JF - Environmental and Molecular Mutagenesis

SN - 0893-6692

IS - 6

ER -