Occupational exposure to manganese and fine motor skills in elderly men: Results from the Heinz Nixdorf Recall Study

Beate Pesch, Swaantje Casjens, Tobias Weiss, Benjamin Kendzia, Marina Arendt, Lewin Eisele, Thomas Behrens, Nadin Ulrich, Noreen Pundt, Anja Marr, Sibylle Robens, Christoph Van Thriel, Rainer Van Gelder, Michael Aschner, Susanne Moebus, Nico Dragano, Thomas Brüning, Karl Heinz Jöckel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Exposure to manganese (Mn) may cause movement disorders, but less is known whether the effects persist after the termination of exposure. This study investigated the association between former exposure to Mn and fine motor deficits in elderly men from an industrial area with steel production. Methods: Data on the occupational history and fine motor tests were obtained from the second follow-up of the prospective Heinz Nixdorf Recall Study (2011-2014). The study population included 1232 men (median age 68 years). Mn in blood (MnB) was determined in archived samples (2000-2003). The association between Mn exposure (working as welder or in other at-risk occupations, cumulative exposure to inhalable Mn, MnB) with various motor functions (errors in line tracing, steadiness, or aiming and tapping hits) was investigated with Poisson and logistic regression, adjusted for iron status and other covariates. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated for substantially impaired dexterity (errors >90th percentile, tapping hits <10th percentile). Results: The median of cumulative exposure to inhalable Mn was 58 μg m-3 years in 322 men who ever worked in at-risk occupations. Although we observed a partly better motor performance of exposed workers at group level, we found fewer tapping hits in men with cumulative Mn exposure >184.8 μg m-3 years (OR 2.15, 95% CI 1.17-3.94). MnB ≥ 15 μg l-1, serum ferritin ≥ 400 μg l-1, and gamma-glutamyl transferase ≥74 U l-1 were associated with a greater number of errors in line tracing. Conclusions: We found evidence that exposure to inhalable Mn may carry a risk for dexterity deficits. Whether these deficits can be exclusively attributed to Mn remains to be elucidated, as airborne Mn is strongly correlated with iron in metal fumes, and high ferritin was also associated with errors in line tracing. Furthermore, hand training effects must be taken into account when testing for fine motor skills.

Original languageEnglish (US)
Pages (from-to)1118-1131
Number of pages14
JournalAnnals of Work Exposures and Health
Volume61
Issue number9
DOIs
StatePublished - Nov 1 2017

Fingerprint

Motor Skills
Occupational Exposure
Manganese
Ferritins
Iron
Odds Ratio
Confidence Intervals
Steel
Movement Disorders
Transferases
Occupations
Hand
Logistic Models
Metals
Serum

Keywords

  • Community-based cohort
  • Ferritin
  • Fine motor skills
  • Manganese
  • Welding

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Occupational exposure to manganese and fine motor skills in elderly men : Results from the Heinz Nixdorf Recall Study. / Pesch, Beate; Casjens, Swaantje; Weiss, Tobias; Kendzia, Benjamin; Arendt, Marina; Eisele, Lewin; Behrens, Thomas; Ulrich, Nadin; Pundt, Noreen; Marr, Anja; Robens, Sibylle; Van Thriel, Christoph; Van Gelder, Rainer; Aschner, Michael; Moebus, Susanne; Dragano, Nico; Brüning, Thomas; Jöckel, Karl Heinz.

In: Annals of Work Exposures and Health, Vol. 61, No. 9, 01.11.2017, p. 1118-1131.

Research output: Contribution to journalArticle

Pesch, B, Casjens, S, Weiss, T, Kendzia, B, Arendt, M, Eisele, L, Behrens, T, Ulrich, N, Pundt, N, Marr, A, Robens, S, Van Thriel, C, Van Gelder, R, Aschner, M, Moebus, S, Dragano, N, Brüning, T & Jöckel, KH 2017, 'Occupational exposure to manganese and fine motor skills in elderly men: Results from the Heinz Nixdorf Recall Study', Annals of Work Exposures and Health, vol. 61, no. 9, pp. 1118-1131. https://doi.org/10.1093/annweh/wxx076
Pesch, Beate ; Casjens, Swaantje ; Weiss, Tobias ; Kendzia, Benjamin ; Arendt, Marina ; Eisele, Lewin ; Behrens, Thomas ; Ulrich, Nadin ; Pundt, Noreen ; Marr, Anja ; Robens, Sibylle ; Van Thriel, Christoph ; Van Gelder, Rainer ; Aschner, Michael ; Moebus, Susanne ; Dragano, Nico ; Brüning, Thomas ; Jöckel, Karl Heinz. / Occupational exposure to manganese and fine motor skills in elderly men : Results from the Heinz Nixdorf Recall Study. In: Annals of Work Exposures and Health. 2017 ; Vol. 61, No. 9. pp. 1118-1131.
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abstract = "Objectives: Exposure to manganese (Mn) may cause movement disorders, but less is known whether the effects persist after the termination of exposure. This study investigated the association between former exposure to Mn and fine motor deficits in elderly men from an industrial area with steel production. Methods: Data on the occupational history and fine motor tests were obtained from the second follow-up of the prospective Heinz Nixdorf Recall Study (2011-2014). The study population included 1232 men (median age 68 years). Mn in blood (MnB) was determined in archived samples (2000-2003). The association between Mn exposure (working as welder or in other at-risk occupations, cumulative exposure to inhalable Mn, MnB) with various motor functions (errors in line tracing, steadiness, or aiming and tapping hits) was investigated with Poisson and logistic regression, adjusted for iron status and other covariates. Odds ratios (ORs) with 95{\%} confidence intervals (CIs) were estimated for substantially impaired dexterity (errors >90th percentile, tapping hits <10th percentile). Results: The median of cumulative exposure to inhalable Mn was 58 μg m-3 years in 322 men who ever worked in at-risk occupations. Although we observed a partly better motor performance of exposed workers at group level, we found fewer tapping hits in men with cumulative Mn exposure >184.8 μg m-3 years (OR 2.15, 95{\%} CI 1.17-3.94). MnB ≥ 15 μg l-1, serum ferritin ≥ 400 μg l-1, and gamma-glutamyl transferase ≥74 U l-1 were associated with a greater number of errors in line tracing. Conclusions: We found evidence that exposure to inhalable Mn may carry a risk for dexterity deficits. Whether these deficits can be exclusively attributed to Mn remains to be elucidated, as airborne Mn is strongly correlated with iron in metal fumes, and high ferritin was also associated with errors in line tracing. Furthermore, hand training effects must be taken into account when testing for fine motor skills.",
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AU - Pesch, Beate

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AU - Weiss, Tobias

AU - Kendzia, Benjamin

AU - Arendt, Marina

AU - Eisele, Lewin

AU - Behrens, Thomas

AU - Ulrich, Nadin

AU - Pundt, Noreen

AU - Marr, Anja

AU - Robens, Sibylle

AU - Van Thriel, Christoph

AU - Van Gelder, Rainer

AU - Aschner, Michael

AU - Moebus, Susanne

AU - Dragano, Nico

AU - Brüning, Thomas

AU - Jöckel, Karl Heinz

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N2 - Objectives: Exposure to manganese (Mn) may cause movement disorders, but less is known whether the effects persist after the termination of exposure. This study investigated the association between former exposure to Mn and fine motor deficits in elderly men from an industrial area with steel production. Methods: Data on the occupational history and fine motor tests were obtained from the second follow-up of the prospective Heinz Nixdorf Recall Study (2011-2014). The study population included 1232 men (median age 68 years). Mn in blood (MnB) was determined in archived samples (2000-2003). The association between Mn exposure (working as welder or in other at-risk occupations, cumulative exposure to inhalable Mn, MnB) with various motor functions (errors in line tracing, steadiness, or aiming and tapping hits) was investigated with Poisson and logistic regression, adjusted for iron status and other covariates. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated for substantially impaired dexterity (errors >90th percentile, tapping hits <10th percentile). Results: The median of cumulative exposure to inhalable Mn was 58 μg m-3 years in 322 men who ever worked in at-risk occupations. Although we observed a partly better motor performance of exposed workers at group level, we found fewer tapping hits in men with cumulative Mn exposure >184.8 μg m-3 years (OR 2.15, 95% CI 1.17-3.94). MnB ≥ 15 μg l-1, serum ferritin ≥ 400 μg l-1, and gamma-glutamyl transferase ≥74 U l-1 were associated with a greater number of errors in line tracing. Conclusions: We found evidence that exposure to inhalable Mn may carry a risk for dexterity deficits. Whether these deficits can be exclusively attributed to Mn remains to be elucidated, as airborne Mn is strongly correlated with iron in metal fumes, and high ferritin was also associated with errors in line tracing. Furthermore, hand training effects must be taken into account when testing for fine motor skills.

AB - Objectives: Exposure to manganese (Mn) may cause movement disorders, but less is known whether the effects persist after the termination of exposure. This study investigated the association between former exposure to Mn and fine motor deficits in elderly men from an industrial area with steel production. Methods: Data on the occupational history and fine motor tests were obtained from the second follow-up of the prospective Heinz Nixdorf Recall Study (2011-2014). The study population included 1232 men (median age 68 years). Mn in blood (MnB) was determined in archived samples (2000-2003). The association between Mn exposure (working as welder or in other at-risk occupations, cumulative exposure to inhalable Mn, MnB) with various motor functions (errors in line tracing, steadiness, or aiming and tapping hits) was investigated with Poisson and logistic regression, adjusted for iron status and other covariates. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated for substantially impaired dexterity (errors >90th percentile, tapping hits <10th percentile). Results: The median of cumulative exposure to inhalable Mn was 58 μg m-3 years in 322 men who ever worked in at-risk occupations. Although we observed a partly better motor performance of exposed workers at group level, we found fewer tapping hits in men with cumulative Mn exposure >184.8 μg m-3 years (OR 2.15, 95% CI 1.17-3.94). MnB ≥ 15 μg l-1, serum ferritin ≥ 400 μg l-1, and gamma-glutamyl transferase ≥74 U l-1 were associated with a greater number of errors in line tracing. Conclusions: We found evidence that exposure to inhalable Mn may carry a risk for dexterity deficits. Whether these deficits can be exclusively attributed to Mn remains to be elucidated, as airborne Mn is strongly correlated with iron in metal fumes, and high ferritin was also associated with errors in line tracing. Furthermore, hand training effects must be taken into account when testing for fine motor skills.

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KW - Ferritin

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