Obstructive sleep apnea as a risk factor for coronary events or cardiovascular death

Neomi A. Shah, Henry Klar Yaggi, John Concato, Vahid Mohsenin

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Purpose This study aims to determine whether obstructive sleep apnea independently increases the risk of coronary events, including death from cardiovascular causes. Methods We conducted an observational cohort study among consecutive patients ≥50 years of age who were referred during 1997-2001 to the Yale Center for Sleep Medicine for suspected sleep-disordered breathing and were followed longitudinally for subsequent coronary events or cardiovascular death. Each study participant underwent an overnight polysomnography; obstructive sleep apnea was defined as an apnea-hypopnea index ≥5/h. The composite outcome during a mean duration of follow-up of 2.9 years was myocardial infarction, coronary artery revascularization procedures (angioplasty, stent placement, or coronary artery bypass graft surgery), or death from cardiovascular causes. Results Among 1,436 enrolled patients, 1,024 (71%) had an apnea-hypopnea index ≥5/h. In an unadjusted analysis, obstructive sleep apnea was associated with an increased risk of coronary events or cardiovascular death (hazard ration (HR) 2.57, 95% confidence interval (CI) 1.39-4.72, P=0.003). After adjustment for traditional cardiovascular risk factors (including body mass index and hypertension), obstructive sleep apnea retained a statistically significant association with this composite outcome (HR 2.06, 95% CI 1.10-3.86, P=0.024). Conclusion Obstructive sleep apnea increases the risk of coronary events or death from cardiovascular causes.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalSleep and Breathing
Volume14
Issue number2
DOIs
StatePublished - Jun 2010
Externally publishedYes

Fingerprint

Obstructive Sleep Apnea
Cause of Death
Apnea
Confidence Intervals
Polysomnography
Sleep Apnea Syndromes
Angioplasty
Coronary Artery Bypass
Stents
Observational Studies
Coronary Vessels
Sleep
Body Mass Index
Cohort Studies
Myocardial Infarction
Medicine
Hypertension
Transplants

Keywords

  • Cardiovascular
  • Coronary artery disease
  • Disease
  • Obstructive sleep apnea
  • Sleep

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology

Cite this

Obstructive sleep apnea as a risk factor for coronary events or cardiovascular death. / Shah, Neomi A.; Yaggi, Henry Klar; Concato, John; Mohsenin, Vahid.

In: Sleep and Breathing, Vol. 14, No. 2, 06.2010, p. 131-136.

Research output: Contribution to journalArticle

Shah, Neomi A. ; Yaggi, Henry Klar ; Concato, John ; Mohsenin, Vahid. / Obstructive sleep apnea as a risk factor for coronary events or cardiovascular death. In: Sleep and Breathing. 2010 ; Vol. 14, No. 2. pp. 131-136.
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