Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population

Alberto R. Ramos, Wassim Tarraf, Tatjana Rundek, Susan Redline, William K. Wohlgemuth, Jose S. Loredo, Ralph L. Sacco, David J. Lee, Raanan Arens, Patricia Lazalde, James P. Choca, Thomas Mosley, Hector M. González

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: We evaluated the association between obstructive sleep apnea (OSA) and neurocognitive function among community-dwelling Hispanic/Latino individuals in the United States. Methods: Cross-sectional analysis of the Hispanic Community Health Study/Study of Latinos middle-aged and older adults, aged 45 to 74 years, with neurocognitive test scores at baseline measurements from 2008 to 2011. Neurocognitive scores were measured using the Word Fluency (WF) Test, the Brief-Spanish English Verbal Learning Test (SEVLT), and the Digit Symbol Substitution (DSS) Test. OSA was defined by the apnea-hypopnea index (AHI). Multivariable linear regression models were fit to evaluate relations between OSA and neurocognitive scores. Results: The analysis consisted of 8,059 participants, mean age of 56 years, 55% women, and 41% with less than high school education. The mean AHI was 9.0 (range 0-142; normal AHI <5/h). There was an association between the AHI and all 4 neurocognitive test scores: Brief-SEVLT-sum (β =-0.022) and-recall (β =-0.010), WF (β =-20.023), and DSS (β =-0.050) at p < 0.01 that was fully attenuated by age. In the fully adjusted regression model, female sex was a moderating factor between the AHI and WF (β =-0.027, p < 0.10), SVELT-sum (β =-0.37), SVELT-recall (β =-0.010), and DSS (β =-0.061) at p < 0.01. Conclusion: OSA was associated with worse neurocognitive function in a representative sample of Hispanic/Latino women in the United States.

Original languageEnglish (US)
Pages (from-to)391-398
Number of pages8
JournalNeurology
Volume84
Issue number4
DOIs
StatePublished - 2015

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Obstructive Sleep Apnea
Hispanic Americans
Apnea
Population
Verbal Learning
Linear Models
Independent Living
Cross-Sectional Studies
Education
Health

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Ramos, A. R., Tarraf, W., Rundek, T., Redline, S., Wohlgemuth, W. K., Loredo, J. S., ... González, H. M. (2015). Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population. Neurology, 84(4), 391-398. https://doi.org/10.1212/WNL.0000000000001181

Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population. / Ramos, Alberto R.; Tarraf, Wassim; Rundek, Tatjana; Redline, Susan; Wohlgemuth, William K.; Loredo, Jose S.; Sacco, Ralph L.; Lee, David J.; Arens, Raanan; Lazalde, Patricia; Choca, James P.; Mosley, Thomas; González, Hector M.

In: Neurology, Vol. 84, No. 4, 2015, p. 391-398.

Research output: Contribution to journalArticle

Ramos, AR, Tarraf, W, Rundek, T, Redline, S, Wohlgemuth, WK, Loredo, JS, Sacco, RL, Lee, DJ, Arens, R, Lazalde, P, Choca, JP, Mosley, T & González, HM 2015, 'Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population', Neurology, vol. 84, no. 4, pp. 391-398. https://doi.org/10.1212/WNL.0000000000001181
Ramos AR, Tarraf W, Rundek T, Redline S, Wohlgemuth WK, Loredo JS et al. Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population. Neurology. 2015;84(4):391-398. https://doi.org/10.1212/WNL.0000000000001181
Ramos, Alberto R. ; Tarraf, Wassim ; Rundek, Tatjana ; Redline, Susan ; Wohlgemuth, William K. ; Loredo, Jose S. ; Sacco, Ralph L. ; Lee, David J. ; Arens, Raanan ; Lazalde, Patricia ; Choca, James P. ; Mosley, Thomas ; González, Hector M. / Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population. In: Neurology. 2015 ; Vol. 84, No. 4. pp. 391-398.
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abstract = "Objective: We evaluated the association between obstructive sleep apnea (OSA) and neurocognitive function among community-dwelling Hispanic/Latino individuals in the United States. Methods: Cross-sectional analysis of the Hispanic Community Health Study/Study of Latinos middle-aged and older adults, aged 45 to 74 years, with neurocognitive test scores at baseline measurements from 2008 to 2011. Neurocognitive scores were measured using the Word Fluency (WF) Test, the Brief-Spanish English Verbal Learning Test (SEVLT), and the Digit Symbol Substitution (DSS) Test. OSA was defined by the apnea-hypopnea index (AHI). Multivariable linear regression models were fit to evaluate relations between OSA and neurocognitive scores. Results: The analysis consisted of 8,059 participants, mean age of 56 years, 55{\%} women, and 41{\%} with less than high school education. The mean AHI was 9.0 (range 0-142; normal AHI <5/h). There was an association between the AHI and all 4 neurocognitive test scores: Brief-SEVLT-sum (β =-0.022) and-recall (β =-0.010), WF (β =-20.023), and DSS (β =-0.050) at p < 0.01 that was fully attenuated by age. In the fully adjusted regression model, female sex was a moderating factor between the AHI and WF (β =-0.027, p < 0.10), SVELT-sum (β =-0.37), SVELT-recall (β =-0.010), and DSS (β =-0.061) at p < 0.01. Conclusion: OSA was associated with worse neurocognitive function in a representative sample of Hispanic/Latino women in the United States.",
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AU - Wohlgemuth, William K.

AU - Loredo, Jose S.

AU - Sacco, Ralph L.

AU - Lee, David J.

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AU - Mosley, Thomas

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