Obstetric conditions and erythropoietin levels

Jonathan D. Goldstein, David J. Garry, Dev Maulik

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

OBJECTIVE: Our purpose was to evaluate and compare erythropoietin levels as related to obstetric conditions, including acute and chronic bleeding, preeclampsia and multiple gestations. STUDY DESIGN: During April 1999 all women in the labor and delivery unit with delivery expected to occur within 24 to 72 hours of admission had erythropoietin and hematocrit values obtained. First-trimester hematocrit values, obstetric problems, medications, and history of vaginal bleeding were obtained from patient interview, examination, and the prenatal record. Statistics were analyzed by the student t test and χ2. RESULTS: During a 1-month period, 302 consecutive women were divided into 5 groups on the basis of obstetric events. Group 1 consisted of women with normal, uncomplicated term singleton gestations (n = 230); group 2, women with acute vaginal bleeding (n = 10); group 3, women with chronic vaginal bleeding (n = 29); group 4, women with multiple gestations (n = 13); and group 5, women with preeclampsia (n = 16). The mean erythropoietin level in group 1 (20.2 ± 10.3 mU/mL) was significantly different from values in the other 4 groups (group 2, 74.2 ± 29.2 mU/mL; group 3, 65.0 ± 33.0 mU/mL; group 4, 34.8 ± 16.8 mU/mL; group 5, 43.4 ± 11.4 mU/mL; P < .001). The admission hematocrit for group 1 (0.369 ± 0.029) was significantly greater than for groups 2 and 3 (group 2, 0.323 ± 0.024 group 3, 0.321 ± 0.023; P < .001) and significantly lower than for group 5 (0.384 ± 0.022; P < .05). CONCLUSION: The maternal serum erythropoietin level varies depending on the events occurring during gestation. Acute and chronic bleeding, multiple gestations, and preeclampsia are all associated with various serum erythropoietin levels.

Original languageEnglish (US)
Pages (from-to)1055-1057
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume182
Issue number5
DOIs
Publication statusPublished - Jan 1 2000

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Keywords

  • Erythropoietin
  • Hematocrit
  • Preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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