Observational Study Design in Veterinary Pathology, Part 1

Study Design

Jeff L. Caswell, Laura L. Bassel, Jamie L. Rothenburger, Andrea Gröne, Jan M. Sargeant, Amanda P. Beck, Stina Ekman, Katherine N. Gibson-Corley, Thijs Kuiken, Elise E.B. LaDouceur, David K. Meyerholz, Francesco C. Origgi, Horst Posthaus, Simon L. Priestnall, Lorenzo Ressel, Leslie Sharkey, Leandro B.C. Teixeira, Kazuyuki Uchida, Jerrold M. Ward, Joshua D. Webster & 1 others Jyoji Yamate

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

Observational studies are the basis for much of our knowledge of veterinary pathology and are highly relevant to the daily practice of pathology. However, recommendations for conducting pathology-based observational studies are not readily available. In part 1 of this series, we offer advice on planning and conducting an observational study with examples from the veterinary pathology literature. Investigators should recognize the importance of creativity, insight, and innovation in devising studies that solve problems and fill important gaps in knowledge. Studies should focus on specific and testable hypotheses, questions, or objectives. The methodology is developed to support these goals. We consider the merits and limitations of different types of analytic and descriptive studies, as well as of prospective vs retrospective enrollment. Investigators should define clear inclusion and exclusion criteria and select adequate numbers of study subjects, including careful selection of the most appropriate controls. Studies of causality must consider the temporal relationships between variables and the advantages of measuring incident cases rather than prevalent cases. Investigators must consider unique aspects of studies based on archived laboratory case material and take particular care to consider and mitigate the potential for selection bias and information bias. We close by discussing approaches to adding value and impact to observational studies. Part 2 of the series focuses on methodology and validation of methods.

Original languageEnglish (US)
Pages (from-to)607-621
Number of pages15
JournalVeterinary Pathology
Volume55
Issue number5
DOIs
StatePublished - Sep 1 2018

Fingerprint

Veterinary Pathology
observational studies
Observational Studies
experimental design
Research Personnel
Pathology
descriptive studies
Creativity
Selection Bias
Causality
planning
methodology

Keywords

  • bias
  • case control
  • cohort
  • descriptive studies
  • epidemiology
  • hypothesis
  • laboratory medicine
  • observational studies
  • pathology
  • reproducibility of results
  • research design
  • study design

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Caswell, J. L., Bassel, L. L., Rothenburger, J. L., Gröne, A., Sargeant, J. M., Beck, A. P., ... Yamate, J. (2018). Observational Study Design in Veterinary Pathology, Part 1: Study Design. Veterinary Pathology, 55(5), 607-621. https://doi.org/10.1177/0300985818785705

Observational Study Design in Veterinary Pathology, Part 1 : Study Design. / Caswell, Jeff L.; Bassel, Laura L.; Rothenburger, Jamie L.; Gröne, Andrea; Sargeant, Jan M.; Beck, Amanda P.; Ekman, Stina; Gibson-Corley, Katherine N.; Kuiken, Thijs; LaDouceur, Elise E.B.; Meyerholz, David K.; Origgi, Francesco C.; Posthaus, Horst; Priestnall, Simon L.; Ressel, Lorenzo; Sharkey, Leslie; Teixeira, Leandro B.C.; Uchida, Kazuyuki; Ward, Jerrold M.; Webster, Joshua D.; Yamate, Jyoji.

In: Veterinary Pathology, Vol. 55, No. 5, 01.09.2018, p. 607-621.

Research output: Contribution to journalComment/debate

Caswell, JL, Bassel, LL, Rothenburger, JL, Gröne, A, Sargeant, JM, Beck, AP, Ekman, S, Gibson-Corley, KN, Kuiken, T, LaDouceur, EEB, Meyerholz, DK, Origgi, FC, Posthaus, H, Priestnall, SL, Ressel, L, Sharkey, L, Teixeira, LBC, Uchida, K, Ward, JM, Webster, JD & Yamate, J 2018, 'Observational Study Design in Veterinary Pathology, Part 1: Study Design', Veterinary Pathology, vol. 55, no. 5, pp. 607-621. https://doi.org/10.1177/0300985818785705
Caswell JL, Bassel LL, Rothenburger JL, Gröne A, Sargeant JM, Beck AP et al. Observational Study Design in Veterinary Pathology, Part 1: Study Design. Veterinary Pathology. 2018 Sep 1;55(5):607-621. https://doi.org/10.1177/0300985818785705
Caswell, Jeff L. ; Bassel, Laura L. ; Rothenburger, Jamie L. ; Gröne, Andrea ; Sargeant, Jan M. ; Beck, Amanda P. ; Ekman, Stina ; Gibson-Corley, Katherine N. ; Kuiken, Thijs ; LaDouceur, Elise E.B. ; Meyerholz, David K. ; Origgi, Francesco C. ; Posthaus, Horst ; Priestnall, Simon L. ; Ressel, Lorenzo ; Sharkey, Leslie ; Teixeira, Leandro B.C. ; Uchida, Kazuyuki ; Ward, Jerrold M. ; Webster, Joshua D. ; Yamate, Jyoji. / Observational Study Design in Veterinary Pathology, Part 1 : Study Design. In: Veterinary Pathology. 2018 ; Vol. 55, No. 5. pp. 607-621.
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