Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos

Jun Li; Simin Hua; Guo Chong Chen; Garrett Strizich; Mark H. Kuniholm; Zhilei Shan; Gregory A. Talavera; Sheila F. Castañeda; Marc D. Gellman; Jianwen Cai; Scott J. Cotler; Xuehong Zhang; Frank B. Hu; Robert Kaplan; Carmen R. Isasi; Qibin Qi

doi:10.1111/liv.14514

Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos

Jun Li, Simin Hua, Guo Chong Chen, Garrett Strizich, Mark H. Kuniholm, Zhilei Shan, Gregory A. Talavera, Sheila F. Castañeda, Marc D. Gellman, Jianwen Cai, Scott J. Cotler, Xuehong Zhang, Frank B. Hu, Robert Kaplan, Carmen R. Isasi, Qibin Qi

Epidemiology & Population Health

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background & Aims: Sedentariness and physical inactiveness are associated with deleterious health outcomes, but their associations with liver enzyme elevations remain uncertain. Methods: In 10 385 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos, we examined associations of sedentary time and moderate-to-vigorous physical activity (MVPA) measured by accelerometers with liver enzyme elevations. Elevated alanine aminotransferase (ALT), aspartate aminotransferase and γ-glutamyltransferase (GGT) were defined as the highest gender-specific deciles. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated using weighted Poisson regressions. Results: After adjusting for demographical/socioeconomic factors and MVPA, increasing quartiles of sedentary time were associated with a higher prevalence of elevated ALT (PRs [95% CI] = 1.0, 1.17 [0.92-1.47], 1.21 [0.96, 1.53] and 1.51 [1.13-2.02]; P-trend =.007) and elevated GGT (PRs [95% CI] = 1.0, 1.06 [0.82-1.36], 1.35 [1.06-1.73] and 1.66 [1.27-2.16]; P-trend =.0001). These associations were attenuated but remained significant after further adjustment for cardiometabolic traits including body-mass index, waist-hip-ratio, lipids and homeostatic model assessment of insulin resistance. In contrast, increasing quartiles of MVPA were associated with a lower prevalence of elevated ALT (PRs [95% CI] =1.0, 0.97 [0.77-1.23], 0.84 [0.66-1.06] and 0.72 [0.54-0.96]; P-trend =.01) after adjusting for demographical/socioeconomic factors and sedentary time, but this association became non-significant after further adjustment for cardiometabolic traits. Notably, the association of sedentary time with GGT elevation was significant both in individuals meeting the US Physical Activity Guidelines for Americans (MVPA ≥150 minutes/week) and in those who did not (both P-trend ≤.003). Conclusions: Our findings suggest that objectively measured sedentary time is independently associated with elevated ALT and GGT in US Hispanics/Latinos.

Original language	English (US)
Pages (from-to)	1883-1894
Number of pages	12
Journal	Liver International
Volume	40
Issue number	8
DOIs	https://doi.org/10.1111/liv.14514
State	Published - Aug 1 2020

Keywords

Hispanic Americans
aminotransferases
non-alcoholic fatty liver disease
physical activity
sedentary lifestyle
γ-Glutamyltransferase

ASJC Scopus subject areas

Hepatology

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10.1111/liv.14514

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Li, J., Hua, S., Chen, G. C., Strizich, G., Kuniholm, M. H., Shan, Z., Talavera, G. A., Castañeda, S. F., Gellman, M. D., Cai, J., Cotler, S. J., Zhang, X., Hu, F. B., Kaplan, R., Isasi, C. R., & Qi, Q. (2020). Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos. Liver International, 40(8), 1883-1894. https://doi.org/10.1111/liv.14514

Li, J, Hua, S, Chen, GC, Strizich, G, Kuniholm, MH, Shan, Z, Talavera, GA, Castañeda, SF, Gellman, MD, Cai, J, Cotler, SJ, Zhang, X, Hu, FB, Kaplan, R , Isasi, CR & Qi, Q 2020, 'Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos', Liver International, vol. 40, no. 8, pp. 1883-1894. https://doi.org/10.1111/liv.14514

@article{11202edeac4e4db9ae8dd7b728854aba,

title = "Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos",

abstract = "Background & Aims: Sedentariness and physical inactiveness are associated with deleterious health outcomes, but their associations with liver enzyme elevations remain uncertain. Methods: In 10 385 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos, we examined associations of sedentary time and moderate-to-vigorous physical activity (MVPA) measured by accelerometers with liver enzyme elevations. Elevated alanine aminotransferase (ALT), aspartate aminotransferase and γ-glutamyltransferase (GGT) were defined as the highest gender-specific deciles. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated using weighted Poisson regressions. Results: After adjusting for demographical/socioeconomic factors and MVPA, increasing quartiles of sedentary time were associated with a higher prevalence of elevated ALT (PRs [95% CI] = 1.0, 1.17 [0.92-1.47], 1.21 [0.96, 1.53] and 1.51 [1.13-2.02]; P-trend =.007) and elevated GGT (PRs [95% CI] = 1.0, 1.06 [0.82-1.36], 1.35 [1.06-1.73] and 1.66 [1.27-2.16]; P-trend =.0001). These associations were attenuated but remained significant after further adjustment for cardiometabolic traits including body-mass index, waist-hip-ratio, lipids and homeostatic model assessment of insulin resistance. In contrast, increasing quartiles of MVPA were associated with a lower prevalence of elevated ALT (PRs [95% CI] =1.0, 0.97 [0.77-1.23], 0.84 [0.66-1.06] and 0.72 [0.54-0.96]; P-trend =.01) after adjusting for demographical/socioeconomic factors and sedentary time, but this association became non-significant after further adjustment for cardiometabolic traits. Notably, the association of sedentary time with GGT elevation was significant both in individuals meeting the US Physical Activity Guidelines for Americans (MVPA ≥150 minutes/week) and in those who did not (both P-trend ≤.003). Conclusions: Our findings suggest that objectively measured sedentary time is independently associated with elevated ALT and GGT in US Hispanics/Latinos.",

keywords = "Hispanic Americans, aminotransferases, non-alcoholic fatty liver disease, physical activity, sedentary lifestyle, γ-Glutamyltransferase",

author = "Jun Li and Simin Hua and Chen, {Guo Chong} and Garrett Strizich and Kuniholm, {Mark H.} and Zhilei Shan and Talavera, {Gregory A.} and Casta{\~n}eda, {Sheila F.} and Gellman, {Marc D.} and Jianwen Cai and Cotler, {Scott J.} and Xuehong Zhang and Hu, {Frank B.} and Robert Kaplan and Isasi, {Carmen R.} and Qibin Qi",

note = "Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2020",

month = aug,

day = "1",

doi = "10.1111/liv.14514",

language = "English (US)",

volume = "40",

pages = "1883--1894",

journal = "Liver International",

issn = "1478-3223",

publisher = "Wiley-Blackwell",

number = "8",

}

TY - JOUR

T1 - Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos

AU - Li, Jun

AU - Hua, Simin

AU - Chen, Guo Chong

AU - Strizich, Garrett

AU - Kuniholm, Mark H.

AU - Shan, Zhilei

AU - Talavera, Gregory A.

AU - Castañeda, Sheila F.

AU - Gellman, Marc D.

AU - Cai, Jianwen

AU - Cotler, Scott J.

AU - Zhang, Xuehong

AU - Hu, Frank B.

AU - Kaplan, Robert

AU - Isasi, Carmen R.

AU - Qi, Qibin

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Background & Aims: Sedentariness and physical inactiveness are associated with deleterious health outcomes, but their associations with liver enzyme elevations remain uncertain. Methods: In 10 385 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos, we examined associations of sedentary time and moderate-to-vigorous physical activity (MVPA) measured by accelerometers with liver enzyme elevations. Elevated alanine aminotransferase (ALT), aspartate aminotransferase and γ-glutamyltransferase (GGT) were defined as the highest gender-specific deciles. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated using weighted Poisson regressions. Results: After adjusting for demographical/socioeconomic factors and MVPA, increasing quartiles of sedentary time were associated with a higher prevalence of elevated ALT (PRs [95% CI] = 1.0, 1.17 [0.92-1.47], 1.21 [0.96, 1.53] and 1.51 [1.13-2.02]; P-trend =.007) and elevated GGT (PRs [95% CI] = 1.0, 1.06 [0.82-1.36], 1.35 [1.06-1.73] and 1.66 [1.27-2.16]; P-trend =.0001). These associations were attenuated but remained significant after further adjustment for cardiometabolic traits including body-mass index, waist-hip-ratio, lipids and homeostatic model assessment of insulin resistance. In contrast, increasing quartiles of MVPA were associated with a lower prevalence of elevated ALT (PRs [95% CI] =1.0, 0.97 [0.77-1.23], 0.84 [0.66-1.06] and 0.72 [0.54-0.96]; P-trend =.01) after adjusting for demographical/socioeconomic factors and sedentary time, but this association became non-significant after further adjustment for cardiometabolic traits. Notably, the association of sedentary time with GGT elevation was significant both in individuals meeting the US Physical Activity Guidelines for Americans (MVPA ≥150 minutes/week) and in those who did not (both P-trend ≤.003). Conclusions: Our findings suggest that objectively measured sedentary time is independently associated with elevated ALT and GGT in US Hispanics/Latinos.

AB - Background & Aims: Sedentariness and physical inactiveness are associated with deleterious health outcomes, but their associations with liver enzyme elevations remain uncertain. Methods: In 10 385 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos, we examined associations of sedentary time and moderate-to-vigorous physical activity (MVPA) measured by accelerometers with liver enzyme elevations. Elevated alanine aminotransferase (ALT), aspartate aminotransferase and γ-glutamyltransferase (GGT) were defined as the highest gender-specific deciles. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated using weighted Poisson regressions. Results: After adjusting for demographical/socioeconomic factors and MVPA, increasing quartiles of sedentary time were associated with a higher prevalence of elevated ALT (PRs [95% CI] = 1.0, 1.17 [0.92-1.47], 1.21 [0.96, 1.53] and 1.51 [1.13-2.02]; P-trend =.007) and elevated GGT (PRs [95% CI] = 1.0, 1.06 [0.82-1.36], 1.35 [1.06-1.73] and 1.66 [1.27-2.16]; P-trend =.0001). These associations were attenuated but remained significant after further adjustment for cardiometabolic traits including body-mass index, waist-hip-ratio, lipids and homeostatic model assessment of insulin resistance. In contrast, increasing quartiles of MVPA were associated with a lower prevalence of elevated ALT (PRs [95% CI] =1.0, 0.97 [0.77-1.23], 0.84 [0.66-1.06] and 0.72 [0.54-0.96]; P-trend =.01) after adjusting for demographical/socioeconomic factors and sedentary time, but this association became non-significant after further adjustment for cardiometabolic traits. Notably, the association of sedentary time with GGT elevation was significant both in individuals meeting the US Physical Activity Guidelines for Americans (MVPA ≥150 minutes/week) and in those who did not (both P-trend ≤.003). Conclusions: Our findings suggest that objectively measured sedentary time is independently associated with elevated ALT and GGT in US Hispanics/Latinos.

KW - Hispanic Americans

KW - aminotransferases

KW - non-alcoholic fatty liver disease

KW - physical activity

KW - sedentary lifestyle

KW - γ-Glutamyltransferase

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UR - http://www.scopus.com/inward/citedby.url?scp=85085519985&partnerID=8YFLogxK

U2 - 10.1111/liv.14514

DO - 10.1111/liv.14514

M3 - Article

C2 - 32410310

AN - SCOPUS:85085519985

SN - 1478-3223

VL - 40

SP - 1883

EP - 1894

JO - Liver International

JF - Liver International

IS - 8

ER -

Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos

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