@article{11202edeac4e4db9ae8dd7b728854aba,
title = "Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos",
abstract = "Background & Aims: Sedentariness and physical inactiveness are associated with deleterious health outcomes, but their associations with liver enzyme elevations remain uncertain. Methods: In 10 385 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos, we examined associations of sedentary time and moderate-to-vigorous physical activity (MVPA) measured by accelerometers with liver enzyme elevations. Elevated alanine aminotransferase (ALT), aspartate aminotransferase and γ-glutamyltransferase (GGT) were defined as the highest gender-specific deciles. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated using weighted Poisson regressions. Results: After adjusting for demographical/socioeconomic factors and MVPA, increasing quartiles of sedentary time were associated with a higher prevalence of elevated ALT (PRs [95% CI] = 1.0, 1.17 [0.92-1.47], 1.21 [0.96, 1.53] and 1.51 [1.13-2.02]; P-trend =.007) and elevated GGT (PRs [95% CI] = 1.0, 1.06 [0.82-1.36], 1.35 [1.06-1.73] and 1.66 [1.27-2.16]; P-trend =.0001). These associations were attenuated but remained significant after further adjustment for cardiometabolic traits including body-mass index, waist-hip-ratio, lipids and homeostatic model assessment of insulin resistance. In contrast, increasing quartiles of MVPA were associated with a lower prevalence of elevated ALT (PRs [95% CI] =1.0, 0.97 [0.77-1.23], 0.84 [0.66-1.06] and 0.72 [0.54-0.96]; P-trend =.01) after adjusting for demographical/socioeconomic factors and sedentary time, but this association became non-significant after further adjustment for cardiometabolic traits. Notably, the association of sedentary time with GGT elevation was significant both in individuals meeting the US Physical Activity Guidelines for Americans (MVPA ≥150 minutes/week) and in those who did not (both P-trend ≤.003). Conclusions: Our findings suggest that objectively measured sedentary time is independently associated with elevated ALT and GGT in US Hispanics/Latinos.",
keywords = "Hispanic Americans, aminotransferases, non-alcoholic fatty liver disease, physical activity, sedentary lifestyle, γ-Glutamyltransferase",
author = "Jun Li and Simin Hua and Chen, {Guo Chong} and Garrett Strizich and Kuniholm, {Mark H.} and Zhilei Shan and Talavera, {Gregory A.} and Casta{\~n}eda, {Sheila F.} and Gellman, {Marc D.} and Jianwen Cai and Cotler, {Scott J.} and Xuehong Zhang and Hu, {Frank B.} and Robert Kaplan and Isasi, {Carmen R.} and Qibin Qi",
note = "Funding Information: The baseline examination of the Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01‐HC65233), University of Miami (N01‐HC65234), Albert Einstein College of Medicine (N01‐HC65235), Northwestern University (N01‐HC65236) and San Diego State University (N01‐HC65237). The following Institutes/Centres/Offices contributed to the HCHS/SOL first funding period through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke and the NIH Office of Dietary Supplements. The Genetic Analysis Center at the University of Washington was supported by NHLBI and NIDCR contracts (HHSN268201300005C AM03 and MOD03). Genotyping efforts were supported by NHLBI HSN 26220/20054C, NCATS CTSI grant UL1TR000123 and NIDDK Diabetes Research Center (DRC) grant DK063491. Dr. Qibin Qi is supported by R01DK119268 from the NIDDK, and R01HL060712 and R01HL140976 from the NHLBI. Dr. Jun Li is a recipient of American Diabetes Association‐Pfizer New England Cardiovascular‐Metabolic Fellowship Award (9‐17‐CMF‐011). Dr. Sheila Casta{\~n}eda was supported in part by a grant from American Heart Association (16SFRN27940007). The funders had no role in study design, data collection, data analysis, data interpretation, the writing of the report or decision of publication of the results. Funding Information: The baseline examination of the Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236) and San Diego State University (N01-HC65237). The following Institutes/Centres/Offices contributed to the HCHS/SOL first funding period through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke and the NIH Office of Dietary Supplements. The Genetic Analysis Center at the University of Washington was supported by NHLBI and NIDCR contracts (HHSN268201300005C AM03 and MOD03). Genotyping efforts were supported by NHLBI HSN 26220/20054C, NCATS CTSI grant UL1TR000123 and NIDDK Diabetes Research Center (DRC) grant DK063491. Dr. Qibin Qi is supported by R01DK119268 from the NIDDK, and R01HL060712 and R01HL140976 from the NHLBI. Dr. Jun Li is a recipient of American Diabetes Association-Pfizer New England Cardiovascular-Metabolic Fellowship Award (9-17-CMF-011). Dr. Sheila Casta?eda was supported in part by a grant from American Heart Association (16SFRN27940007). The funders had no role in study design, data collection, data analysis, data interpretation, the writing of the report or decision of publication of the results. Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2020",
month = aug,
day = "1",
doi = "10.1111/liv.14514",
language = "English (US)",
volume = "40",
pages = "1883--1894",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "8",
}