Obesity genes

Molecular and metabolic mechanisms

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Within the past 3 years, all of the extant single-gene mutations resulting in obesity in rodents have been cloned. These mutations are Yellow, obese, diabetes, fat, and tubby. The rat fatty mutation, as predicted by earlier mapping experiments, is a molecular homologue of the mouse mutation diabetes. The fundamental principles of the physiology of energy metabolism, and the phenotypes of these animals in particular, suggested that their obesity must reflect alterations in any or all of the following processes: energy intake, energy expenditure, or the partitioning of energy between adipose tissue and lean tissues. Transgenic animals exemplifying discrete aberrations in each one of these processes confirm this conceptual framework. The early characterizations of the respective genes in the mutant rodents have elucidated novel, heretofore unknown, components of systems for the regulation and maintenance of body fat, in terms of both absolute fat mass as well as the relative amount of fat as a percentage of body mass. All of these newly identified genes have highly conserved human homologues that presumably play roles in comparable systems in humans. Genetic linkage and mutation studies are underway to test this possibility. Meanwhile, the further characterization of these mutations will undoubtedly lead to the discovery of new molecules as well as molecular links to known systems involved in mediating their effects on body fat content.

Original languageEnglish (US)
Pages (from-to)2-7
Number of pages6
JournalDiabetes Reviews
Volume5
Issue number1
StatePublished - 1997
Externally publishedYes

Fingerprint

Obesity
Mutation
Genes
Adipose Tissue
Fats
Energy Metabolism
Rodentia
Genetically Modified Animals
Genetic Linkage
Energy Intake
Maintenance
Phenotype

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Obesity genes : Molecular and metabolic mechanisms. / Chua, Jr., Streamson C.; Leibel, R. L.

In: Diabetes Reviews, Vol. 5, No. 1, 1997, p. 2-7.

Research output: Contribution to journalArticle

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