Obesity, fasting plasma insulin, and C-reactive protein levels in healthy children

Steven Shea, Eve Aymong, Patricia Zybert, Harry Shamoon, Russell P. Tracy, Richard J. Deckelbaum, Charles E. Basch

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objective: Obesity is associated with hyperinsulinemia and increased level of C-reactive protein in older children and adults, but little is known about these relationships in very young children. We examined these relationships in healthy 2- to 3-year-old children. Research Methods and Procedures: Analyses were performed on data from 491 healthy 2- to 3-year-old Hispanic children enrolled in a dietary study conducted in New York City, 1992 to 1995. Results: Body mass index (BMI), ponderal index, and sum of four skinfolds were highly correlated (r > 0.75) in both boys and girls. Fasting insulin and glucose levels were only modestly correlated (r = 0.37 for boys and r = 0.28 for girls; p < 0.001 for both), but essentially all of the variability in a calculated index of insulin resistance was attributable to variability in fasting insulin level. The correlations of BMI with fasting insulin level were r = 0.16 (p < 0.05) in boys and r = 0.14 (p < 0.05) in girls. In separate multivariate regression analyses adjusting for age and sex, BMI and ponderal index were associated with fasting plasma insulin level (p < 0.001 for both obesity measures). In multivariate regression analyses adjusting simultaneously for age, sex, and either BMI or ponderal index, fasting insulin level, but not these obesity measures, was associated with C-reactive protein level. Discussion: Obesity is associated with higher fasting insulin level, and fasting insulin is associated with C-reactive protein level, in healthy 2- to 3-year-old children.

Original languageEnglish (US)
Pages (from-to)95-103
Number of pages9
JournalObesity Research
Volume11
Issue number1
StatePublished - 2003

Fingerprint

C-reactive protein
C-Reactive Protein
fasting
Fasting
obesity
insulin
Obesity
Insulin
body mass index
Body Mass Index
Weights and Measures
Multivariate Analysis
Regression Analysis
hyperinsulinemia
gender
Hyperinsulinism
diet study techniques
research methods
Hispanic Americans
insulin resistance

Keywords

  • Adipocity
  • Body mass index
  • C-reactive protein
  • Children
  • Insulin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Shea, S., Aymong, E., Zybert, P., Shamoon, H., Tracy, R. P., Deckelbaum, R. J., & Basch, C. E. (2003). Obesity, fasting plasma insulin, and C-reactive protein levels in healthy children. Obesity Research, 11(1), 95-103.

Obesity, fasting plasma insulin, and C-reactive protein levels in healthy children. / Shea, Steven; Aymong, Eve; Zybert, Patricia; Shamoon, Harry; Tracy, Russell P.; Deckelbaum, Richard J.; Basch, Charles E.

In: Obesity Research, Vol. 11, No. 1, 2003, p. 95-103.

Research output: Contribution to journalArticle

Shea, S, Aymong, E, Zybert, P, Shamoon, H, Tracy, RP, Deckelbaum, RJ & Basch, CE 2003, 'Obesity, fasting plasma insulin, and C-reactive protein levels in healthy children', Obesity Research, vol. 11, no. 1, pp. 95-103.
Shea S, Aymong E, Zybert P, Shamoon H, Tracy RP, Deckelbaum RJ et al. Obesity, fasting plasma insulin, and C-reactive protein levels in healthy children. Obesity Research. 2003;11(1):95-103.
Shea, Steven ; Aymong, Eve ; Zybert, Patricia ; Shamoon, Harry ; Tracy, Russell P. ; Deckelbaum, Richard J. ; Basch, Charles E. / Obesity, fasting plasma insulin, and C-reactive protein levels in healthy children. In: Obesity Research. 2003 ; Vol. 11, No. 1. pp. 95-103.
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