Obesity enhances gastrointestinal tumorigenesis in Apc-mutant mice

C. Gravaghi, J. Bo, K. M.D. LaPerle, F. Quimby, R. Kucherlapati, W. Edelmann, S. A. Lamprecht

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Epidemiological evidence indicates a link between obesity and human colon cancer. A putative association between obesity and colon tumorigenesis has been explored experimentally using chemical carcinogens administered to obese rodents. The main objective of this study was to generate a new mouse line that displays both obesity and intestinal tumorigenesis. To this end, we have generated C57BLKS-mLeprdb/db; Apc1638N/+ mice combining both db and Apc mutations. The db mutation results in obesity and type 2 diabetes, the Apc mutation is a key initiating event of intestinal neoplasia. All mice were euthanized at 6 months of age and all regions of the gastrointestinal tract examined for tumors. The results show that the combination of Apc1638N/+ and db mutations not only enhanced mutant Apc-driven small intestinal tumorigenesis but also induced gastric and colonic tumors. Homozygous db mice did not develop gastrointestinal neoplasia. These findings indicate that obesity associated with type 2 diabetes promotes gastrointestinal tumorigenesis in Apc-deficient mice and provides evidence of a mechanistic link between obesity and colorectal neoplasia.

Original languageEnglish (US)
Pages (from-to)1716-1719
Number of pages4
JournalInternational Journal of Obesity
Issue number11
StatePublished - Nov 2008


  • Apc
  • Colon cancer
  • Diabetes
  • db/db

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Obesity enhances gastrointestinal tumorigenesis in Apc-mutant mice'. Together they form a unique fingerprint.

Cite this