TY - JOUR
T1 - Obesity and Psoriatic Arthritis
T2 - A Narrative Review
AU - Kumthekar, Anand
AU - Ogdie, Alexis
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Patients with psoriatic arthritis (PsA) have a higher burden of cardio-metabolic comorbidities like obesity, hypertension, diabetes, and cardiovascular disease compared to the general population. Adipose tissue is thought to promote a chronic low grade inflammatory state through inflammatory mediators like tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), leptin, and adiponectin. A higher body mass index (BMI) is a risk factor for development of PsA and affects disease activity and response to therapy including both disease-modifying anti-rheumatic drugs (DMARDs) and tumor necrosis factor inhibitors (TNFi). Obesity has an impact on the morbidity in PsA, particularly cardiovascular and/or metabolic. Patients with PsA have a higher cardiovascular risk and obesity may have an additive impact on morbidity and mortality. This review explores the relationship between obesity and PsA.
AB - Patients with psoriatic arthritis (PsA) have a higher burden of cardio-metabolic comorbidities like obesity, hypertension, diabetes, and cardiovascular disease compared to the general population. Adipose tissue is thought to promote a chronic low grade inflammatory state through inflammatory mediators like tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), leptin, and adiponectin. A higher body mass index (BMI) is a risk factor for development of PsA and affects disease activity and response to therapy including both disease-modifying anti-rheumatic drugs (DMARDs) and tumor necrosis factor inhibitors (TNFi). Obesity has an impact on the morbidity in PsA, particularly cardiovascular and/or metabolic. Patients with PsA have a higher cardiovascular risk and obesity may have an additive impact on morbidity and mortality. This review explores the relationship between obesity and PsA.
KW - Body mass index (BMI)
KW - Cardiovascular risk
KW - Obesity
KW - Psoriatic arthritis (PsA)
UR - http://www.scopus.com/inward/record.url?scp=85101086479&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85101086479&partnerID=8YFLogxK
U2 - 10.1007/s40744-020-00215-6
DO - 10.1007/s40744-020-00215-6
M3 - Review article
AN - SCOPUS:85101086479
SN - 2198-6576
VL - 7
SP - 447
EP - 456
JO - Rheumatology and Therapy
JF - Rheumatology and Therapy
IS - 3
ER -