Obesity and Psoriatic Arthritis: A Narrative Review

Anand Kumthekar, Alexis Ogdie

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Patients with psoriatic arthritis (PsA) have a higher burden of cardio-metabolic comorbidities like obesity, hypertension, diabetes, and cardiovascular disease compared to the general population. Adipose tissue is thought to promote a chronic low grade inflammatory state through inflammatory mediators like tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), leptin, and adiponectin. A higher body mass index (BMI) is a risk factor for development of PsA and affects disease activity and response to therapy including both disease-modifying anti-rheumatic drugs (DMARDs) and tumor necrosis factor inhibitors (TNFi). Obesity has an impact on the morbidity in PsA, particularly cardiovascular and/or metabolic. Patients with PsA have a higher cardiovascular risk and obesity may have an additive impact on morbidity and mortality. This review explores the relationship between obesity and PsA.

Original languageEnglish (US)
Pages (from-to)447-456
Number of pages10
JournalRheumatology and Therapy
Volume7
Issue number3
DOIs
StatePublished - Sep 1 2020

Keywords

  • Body mass index (BMI)
  • Cardiovascular risk
  • Obesity
  • Psoriatic arthritis (PsA)

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy

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