Abstract
Objective: Previous studies regarding the effect of obesity on serum anti-müllerian hormone (AMH) levels have been conflicting. Our aim was to determine the effect of obesity on serum AMH levels among women from different racial backgrounds. Methods: The medical records of 350 women (159 Caucasian, 99 African-American, 58 Hispanic, 34 Asian with ages 16–46) evaluated for infertility at an academic-affiliated center and who had AMH levels measured as part of their evaluation were reviewed. Age, AMH, body mass index (BMI), self-reported race, etiology of infertility, smoking history, maximum serum early follicular follicle-stimulating hormone (FSH) levels, antral follicle count (AFC), and history of ovarian surgery, chemotherapy, or radiotherapy were recorded. Results: Age correlated negatively with AMH and antral follicle count across all races (p <0.05). After adjusting for age, polycystic ovary syndrome diagnosis, and smoking, elevated BMI had a negative correlation with AMH in Caucasian women (β = 0.17, p = 0.01) but not in African-American, Hispanic, or Asian women. Conclusion: Elevated BMI correlates negatively with AMH in Caucasian women but not in African-American, Hispanic, or Asian women. Additional studies are needed to elucidate further the effect of race on the interaction between obesity and ovarian reserve.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1305-1311 |
| Number of pages | 7 |
| Journal | Journal of Assisted Reproduction and Genetics |
| Volume | 32 |
| Issue number | 9 |
| DOIs | |
| State | Published - Jul 21 2015 |
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Keywords
- Anti-müllerian hormone (AMH)
- Body mass index
- Obesity
- Race/ethnicity
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Reproductive Medicine
- Developmental Biology
- Genetics
- Genetics(clinical)
Cite this
Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women. / Moy, Vicky; Jindal, Sangita K.; Lieman, Harry J.; Buyuk, Erkan.
In: Journal of Assisted Reproduction and Genetics, Vol. 32, No. 9, 21.07.2015, p. 1305-1311.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women
AU - Moy, Vicky
AU - Jindal, Sangita K.
AU - Lieman, Harry J.
AU - Buyuk, Erkan
PY - 2015/7/21
Y1 - 2015/7/21
N2 - Objective: Previous studies regarding the effect of obesity on serum anti-müllerian hormone (AMH) levels have been conflicting. Our aim was to determine the effect of obesity on serum AMH levels among women from different racial backgrounds. Methods: The medical records of 350 women (159 Caucasian, 99 African-American, 58 Hispanic, 34 Asian with ages 16–46) evaluated for infertility at an academic-affiliated center and who had AMH levels measured as part of their evaluation were reviewed. Age, AMH, body mass index (BMI), self-reported race, etiology of infertility, smoking history, maximum serum early follicular follicle-stimulating hormone (FSH) levels, antral follicle count (AFC), and history of ovarian surgery, chemotherapy, or radiotherapy were recorded. Results: Age correlated negatively with AMH and antral follicle count across all races (p <0.05). After adjusting for age, polycystic ovary syndrome diagnosis, and smoking, elevated BMI had a negative correlation with AMH in Caucasian women (β = 0.17, p = 0.01) but not in African-American, Hispanic, or Asian women. Conclusion: Elevated BMI correlates negatively with AMH in Caucasian women but not in African-American, Hispanic, or Asian women. Additional studies are needed to elucidate further the effect of race on the interaction between obesity and ovarian reserve.
AB - Objective: Previous studies regarding the effect of obesity on serum anti-müllerian hormone (AMH) levels have been conflicting. Our aim was to determine the effect of obesity on serum AMH levels among women from different racial backgrounds. Methods: The medical records of 350 women (159 Caucasian, 99 African-American, 58 Hispanic, 34 Asian with ages 16–46) evaluated for infertility at an academic-affiliated center and who had AMH levels measured as part of their evaluation were reviewed. Age, AMH, body mass index (BMI), self-reported race, etiology of infertility, smoking history, maximum serum early follicular follicle-stimulating hormone (FSH) levels, antral follicle count (AFC), and history of ovarian surgery, chemotherapy, or radiotherapy were recorded. Results: Age correlated negatively with AMH and antral follicle count across all races (p <0.05). After adjusting for age, polycystic ovary syndrome diagnosis, and smoking, elevated BMI had a negative correlation with AMH in Caucasian women (β = 0.17, p = 0.01) but not in African-American, Hispanic, or Asian women. Conclusion: Elevated BMI correlates negatively with AMH in Caucasian women but not in African-American, Hispanic, or Asian women. Additional studies are needed to elucidate further the effect of race on the interaction between obesity and ovarian reserve.
KW - Anti-müllerian hormone (AMH)
KW - Body mass index
KW - Obesity
KW - Race/ethnicity
UR - http://www.scopus.com/inward/record.url?scp=84943351450&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943351450&partnerID=8YFLogxK
U2 - 10.1007/s10815-015-0538-7
DO - 10.1007/s10815-015-0538-7
M3 - Article
C2 - 26194744
AN - SCOPUS:84943351450
VL - 32
SP - 1305
EP - 1311
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
SN - 1058-0468
IS - 9
ER -