O-Glycans in Mammalian Notch Signaling

Research output: Chapter in Book/Report/Conference proceedingChapter


Notch signaling occurs following the activation of membrane-bound Notch receptors by canonical Notch ligands expressed in neighboring cells. It is a fundamental requirement for the regulation of cell fate decisions during organellar differentiation in mammals. The extracellular domain of Notch receptors comprises numerous epidermal growth factor-like (EGF) repeats, many of which are modified by glycans O-linked to Ser or Thr at specific consensus sites. This chapter will summarize the nature and functions of O-Fucose, O-Glucose, O-GlcNAc, and O-GalNAc glycans in mammalian cells, mouse development, and human disease. Congenital diseases that arise from reduced addition of O-glycans reveal the importance of these modifications for Notch signaling.

Original languageEnglish (US)
Title of host publicationGlycoscience: Biology and Medicine
PublisherSpringer Japan
Number of pages8
ISBN (Print)9784431548416, 9784431548409
StatePublished - Jan 1 2015


  • Notch ligands
  • Notch receptors
  • Notch signaling
  • O-Fucose
  • O-GalNAc
  • O-GlcNAc
  • O-Glucose
  • O-glycans

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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