O-Glycans in Mammalian Notch Signaling

Pamela Stanley

doi:10.1007/978-4-431-54841-6_165

O-Glycans in Mammalian Notch Signaling

Pamela Stanley

Cell Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Notch signaling occurs following the activation of membrane-bound Notch receptors by canonical Notch ligands expressed in neighboring cells. It is a fundamental requirement for the regulation of cell fate decisions during organellar differentiation in mammals. The extracellular domain of Notch receptors comprises numerous epidermal growth factor-like (EGF) repeats, many of which are modified by glycans O-linked to Ser or Thr at specific consensus sites. This chapter will summarize the nature and functions of O-Fucose, O-Glucose, O-GlcNAc, and O-GalNAc glycans in mammalian cells, mouse development, and human disease. Congenital diseases that arise from reduced addition of O-glycans reveal the importance of these modifications for Notch signaling.

Original language	English (US)
Title of host publication	Glycoscience
Subtitle of host publication	Biology and Medicine
Publisher	Springer Japan
Pages	857-864
Number of pages	8
ISBN (Electronic)	9784431548416
ISBN (Print)	9784431548409
DOIs	https://doi.org/10.1007/978-4-431-54841-6_165
State	Published - Jan 1 2015

Keywords

Notch ligands
Notch receptors
Notch signaling
O-Fucose
O-GalNAc
O-GlcNAc
O-Glucose
O-glycans

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-4-431-54841-6_165

Cite this

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title = "O-Glycans in Mammalian Notch Signaling",

abstract = "Notch signaling occurs following the activation of membrane-bound Notch receptors by canonical Notch ligands expressed in neighboring cells. It is a fundamental requirement for the regulation of cell fate decisions during organellar differentiation in mammals. The extracellular domain of Notch receptors comprises numerous epidermal growth factor-like (EGF) repeats, many of which are modified by glycans O-linked to Ser or Thr at specific consensus sites. This chapter will summarize the nature and functions of O-Fucose, O-Glucose, O-GlcNAc, and O-GalNAc glycans in mammalian cells, mouse development, and human disease. Congenital diseases that arise from reduced addition of O-glycans reveal the importance of these modifications for Notch signaling.",

keywords = "Notch ligands, Notch receptors, Notch signaling, O-Fucose, O-GalNAc, O-GlcNAc, O-Glucose, O-glycans",

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N2 - Notch signaling occurs following the activation of membrane-bound Notch receptors by canonical Notch ligands expressed in neighboring cells. It is a fundamental requirement for the regulation of cell fate decisions during organellar differentiation in mammals. The extracellular domain of Notch receptors comprises numerous epidermal growth factor-like (EGF) repeats, many of which are modified by glycans O-linked to Ser or Thr at specific consensus sites. This chapter will summarize the nature and functions of O-Fucose, O-Glucose, O-GlcNAc, and O-GalNAc glycans in mammalian cells, mouse development, and human disease. Congenital diseases that arise from reduced addition of O-glycans reveal the importance of these modifications for Notch signaling.

AB - Notch signaling occurs following the activation of membrane-bound Notch receptors by canonical Notch ligands expressed in neighboring cells. It is a fundamental requirement for the regulation of cell fate decisions during organellar differentiation in mammals. The extracellular domain of Notch receptors comprises numerous epidermal growth factor-like (EGF) repeats, many of which are modified by glycans O-linked to Ser or Thr at specific consensus sites. This chapter will summarize the nature and functions of O-Fucose, O-Glucose, O-GlcNAc, and O-GalNAc glycans in mammalian cells, mouse development, and human disease. Congenital diseases that arise from reduced addition of O-glycans reveal the importance of these modifications for Notch signaling.

KW - Notch ligands

KW - Notch receptors

KW - Notch signaling

KW - O-Fucose

KW - O-GalNAc

KW - O-GlcNAc

KW - O-Glucose

KW - O-glycans

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M3 - Chapter

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SP - 857

EP - 864

BT - Glycoscience

PB - Springer Japan

ER -

O-Glycans in Mammalian Notch Signaling

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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