O-093. Incidence of second primary tumors in a cohort of head and neck cancer patients in Brazil

A. L. Carvalho, J. Pintos, N. Schlecht, B. V. Oliveira, A. S. Fava, M. P. Curado, L. P. Kowalski, E. L. Franco

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Abstract

Aims: Second primary tumors are an important issue in the follow-up of a cancer patient. About 10-20% of the patients with head and neck cancer will develop a second primary tumor during follow-up period. The objectives of this study were to analyze factors associated with the development of a second primary tumor in head and neck patients and to compare its incidence with that in the general population. Method: Patients were prospectively enrolled in three metropolitan areas as part of a case-control study. Six-hundred and five patients presenting with a previously untreated head and neck cancer were eligible and analyzed in this study. Results: Forty-seven patients (7.8%) developed a second primary cancer. The site of primary tumor was the only important factor associated with risk of a second primary: patients with lip, oral and oropharyngeal cancers had a RR of 2.56 (95% CI 1.2-5.2), compared with larynx and hypopharynx cancer patients. There were 47 second primaries in the cohort, while the expected frequency (based on general population rates) was 14.4, for a standardized incidence ratio of 3.26 (95% CI 2.4-4.3). Conclusions: Patients with lip, oral and oropharyngeal carcinomas had a higher risk of developing a second primary tumor when compared with larynx and hypopharynx cancer patients. Moreover, patients with head and neck cancer showed a higher incidence rate of second primary tumor when compared with the general population.

Original languageEnglish (US)
Pages (from-to)S48
JournalOral Oncology
Volume37
Issue numberSUPPL. 1
StatePublished - Dec 1 2001

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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    Carvalho, A. L., Pintos, J., Schlecht, N., Oliveira, B. V., Fava, A. S., Curado, M. P., Kowalski, L. P., & Franco, E. L. (2001). O-093. Incidence of second primary tumors in a cohort of head and neck cancer patients in Brazil. Oral Oncology, 37(SUPPL. 1), S48.