Nutritional, Genetic, and Molecular Aspects of Manganese Intoxication

Tanara Vieira Peres, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Manganese (Mn) is an essential heavy metal and a neurotoxicant. Daily intake through dietary sources provides the necessary amount of Mn required for several physiological processes, including antioxidant defense, energy metabolism, immune function, and bone development. Nevertheless, excessive exposure to Mn is toxic and may arise from environmental sources, occupational exposure, total parenteral nutrition, or methcathinone drug abuse. Several proteins have been identified to transport Mn, such as divalent metal tranporter-1, SLC30A10 (solute carrier family 30, member 10), transferrin, and ferroportin, to name a few. Accumulation of Mn occurs mainly in basal ganglia and leads to a syndrome called manganism. The molecular mechanisms of Mn neurotoxicity include oxidative stress, mitochondrial impairment, and neurotransmitter dyshomeostasis leading to cognitive dysfunction and motor symptoms similar to Parkinson's disease (PD). Given the similarities between manganism and PD, understanding nutritional and molecular aspects of Mn transport and toxicity may help to understand the mechanisms underlying the etiology of PD and possibly other neurodegenerative disorders.

Original languageEnglish (US)
Title of host publicationMolecular, Genetic, and Nutritional Aspects of Major and Trace Minerals
PublisherElsevier Inc.
Pages367-376
Number of pages10
ISBN (Electronic)9780128023761
ISBN (Print)9780128021682
DOIs
StatePublished - Jan 1 2017

Keywords

  • Manganese neurotoxicity
  • Manganese transporters
  • Parkinson's disease

ASJC Scopus subject areas

  • Medicine(all)

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    Peres, T. V., & Aschner, M. (2017). Nutritional, Genetic, and Molecular Aspects of Manganese Intoxication. In Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals (pp. 367-376). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802168-2.00030-0