Nutritional aspects of manganese homeostasis

Judy L. Aschner, Michael Aschner

Research output: Contribution to journalArticle

352 Citations (Scopus)

Abstract

Manganese (Mn) is an essential mineral. It is present in virtually all diets at low concentrations. The principal route of intake for Mn is via food consumption, but in occupational cohorts, inhalation exposure may also occur (this subject will not be dealt with in this review). Humans maintain stable tissue levels of Mn. This is achieved via tight homeostatic control of both absorption and excretion. Nevertheless, it is well established that exposure to high oral, parenteral or ambient air concentrations of Mn can result in elevations in tissue Mn levels. Excessive Mn accumulation in the central nervous system (CNS) is an established clinical entity, referred to as manganism. It resembles idiopathic Parkinson's disease (IPD) in its clinical features, resulting in adverse neurological effects both in laboratory animals and humans. This review focuses on an area that to date has received little consideration, namely the potential exposure of parenterally fed neonates to exceedingly high Mn concentrations in parenteral nutrition solutions, potentially increasing their risk for Mn-induced adverse health sequelae. The review will consider (1) the essentiality of Mn; (2) the concentration ranges, means and variation of Mn in various foods and infant formulas; (3) the absorption, distribution, and elimination of Mn after oral exposure and (4) the factors that raise a theoretical concern that neonates receiving total parenteral nutrition (TPN) are exposed to excessive dietary Mn.

Original languageEnglish (US)
Pages (from-to)353-362
Number of pages10
JournalMolecular Aspects of Medicine
Volume26
Issue number4-5 SPEC. ISS.
DOIs
StatePublished - Aug 2005
Externally publishedYes

Fingerprint

Manganese
Homeostasis
Nutrition
Parenteral Nutrition Solutions
Tissue
Inhalation Exposure
Food
Infant Formula
Total Parenteral Nutrition
Laboratory Animals
Neurology
Minerals
Parkinson Disease
Animals
Central Nervous System
Air
Health
Diet

Keywords

  • Central nervous system
  • Formula
  • Manganese
  • Total parenteral nutrition

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine

Cite this

Nutritional aspects of manganese homeostasis. / Aschner, Judy L.; Aschner, Michael.

In: Molecular Aspects of Medicine, Vol. 26, No. 4-5 SPEC. ISS., 08.2005, p. 353-362.

Research output: Contribution to journalArticle

Aschner, Judy L. ; Aschner, Michael. / Nutritional aspects of manganese homeostasis. In: Molecular Aspects of Medicine. 2005 ; Vol. 26, No. 4-5 SPEC. ISS. pp. 353-362.
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