Nucleus raphe dorsalis in parkinsonism-dementia complex of Guam

T. Yamamoto, A. Hirano

Research output: Contribution to journalArticle

14 Scopus citations


Recently, morphometric analysis has shown that the nucleus raphe dorsalis, which is presumed to project diffuse serotonergic fibers to the telencephalon, is affected in Alzheimer's disease. A similar study was conducted in this report in two patients with parkinsonism-dementia complex of Guam and a Guamanian control. It demonstrated a significant reduction in the number of large neurons, and the presence of abundant Alzheimer's neurofibrillary tangles in this nucleus.

Original languageEnglish (US)
Pages (from-to)296-299
Number of pages4
JournalActa Neuropathologica
Issue number3-4
StatePublished - Sep 1 1985


  • Alzheimer's disease
  • Morphometry
  • Neurofibrillary tangles
  • Nucleus raphe dorsalis
  • Parkinsonism-dementia complex of Guam

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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