Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides

Andrew J. Griffith; Joe Craft; Janine Evans; Tsuneyo Mimori; John A. Hardin

doi:10.1007/BF00419754

Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides

Andrew J. Griffith, Joe Craft, Janine Evans, Tsuneyo Mimori, John A. Hardin

Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

cDNA encoding the p70 polypeptide subunit of the human Ku autoantigen was isolated. In vitro expression analysis of the cDNA demonstrates that it encodes the entire open reading frame. Nucleotide sequence analysis and comparison to other previously described sequences indicate the existence of several single-nucleotide and amino acid polymorphisms. Southern blot analyses demonstrate the presence of multiple copies of homologous DNA sequences in the human genome. These data support the hypothesis that multiple genes encode a family of Ku(p70)-related polypeptides.

Original language	English (US)
Pages (from-to)	91-97
Number of pages	7
Journal	Molecular Biology Reports
Volume	16
Issue number	2
DOIs	https://doi.org/10.1007/BF00419754
State	Published - May 1992

Keywords

DNA-binding protein
Ku protein
autoantibodies
gene
recombinant DNA
systemic lupus erythematosus

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1007/BF00419754

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Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen : evidence for a family of genes encoding Ku (p70)-related polypeptides. / Griffith, Andrew J.; Craft, Joe; Evans, Janine; Mimori, Tsuneyo; Hardin, John A.

In: Molecular Biology Reports, Vol. 16, No. 2, 05.1992, p. 91-97.

Research output: Contribution to journal › Article › peer-review

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