Nucleocytoplasmic protein shuttling

the direct route in synapse-to-nucleus signaling

Bryen A. Jordan, Michael R. Kreutz

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

In neurons multiple signaling pathways converge in the nucleus to regulate the expression of genes associated with long-term structural changes of synapto-dendritic input. Of pivotal importance for this type of transcriptional regulation is synapse-to-nucleus communication. Several studies suggest that the nuclear transport of proteins from synapses is involved in this signaling process, including evidence that synapses contain proteins with nuclear localization sequences and components of the nuclear import machinery. Here, we review the evidence for synapse-to-nucleus signaling by means of retrograde transport of proteins from distal processes. We discuss the mechanisms involved in their translocation and their role in the control of nuclear gene expression. Finally, we summarize the current thinking regarding the functional implications of nuclear signaling and address open questions in this evolving area of neuroscience.

Original languageEnglish (US)
Pages (from-to)392-401
Number of pages10
JournalTrends in Neurosciences
Volume32
Issue number7
DOIs
StatePublished - Jul 2009

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Synapses
Cell Nucleus Active Transport
Nuclear Proteins
Carrier Proteins
Proteins
Gene Expression
Neurosciences
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nucleocytoplasmic protein shuttling : the direct route in synapse-to-nucleus signaling. / Jordan, Bryen A.; Kreutz, Michael R.

In: Trends in Neurosciences, Vol. 32, No. 7, 07.2009, p. 392-401.

Research output: Contribution to journalArticle

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