Nuclear receptors orchestrate detoxification pathways.

Jayanta Roy-Chowdhury; Joseph Locker; Namita Roy-Chowdhury

doi:10.1016/S1534-5807(03)00131-X

Nuclear receptors orchestrate detoxification pathways.

Jayanta Roy-Chowdhury, Joseph Locker, Namita Roy-Chowdhury

Medicine

Research output: Contribution to journal › Comment/debate › peer-review

27 Scopus citations

Abstract

Two nuclear receptors of xenobiotic drugs, PXR and CAR, are central regulators of detoxification enzymes. New studies extend the role of these receptors to a natural detoxification process. They coordinate induction of proteins for storage, glucuronidation, and canalicular transport of bilirubin.

Original language	English (US)
Pages (from-to)	607-608
Number of pages	2
Journal	Developmental cell
Volume	4
Issue number	5
DOIs	https://doi.org/10.1016/S1534-5807(03)00131-X
State	Published - May 2003

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/S1534-5807(03)00131-X

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title = "Nuclear receptors orchestrate detoxification pathways.",

abstract = "Two nuclear receptors of xenobiotic drugs, PXR and CAR, are central regulators of detoxification enzymes. New studies extend the role of these receptors to a natural detoxification process. They coordinate induction of proteins for storage, glucuronidation, and canalicular transport of bilirubin.",

author = "Jayanta Roy-Chowdhury and Joseph Locker and Namita Roy-Chowdhury",

year = "2003",

month = may,

doi = "10.1016/S1534-5807(03)00131-X",

language = "English (US)",

volume = "4",

pages = "607--608",

journal = "Developmental cell",

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T1 - Nuclear receptors orchestrate detoxification pathways.

AU - Roy-Chowdhury, Jayanta

AU - Locker, Joseph

AU - Roy-Chowdhury, Namita

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Y1 - 2003/5

N2 - Two nuclear receptors of xenobiotic drugs, PXR and CAR, are central regulators of detoxification enzymes. New studies extend the role of these receptors to a natural detoxification process. They coordinate induction of proteins for storage, glucuronidation, and canalicular transport of bilirubin.

AB - Two nuclear receptors of xenobiotic drugs, PXR and CAR, are central regulators of detoxification enzymes. New studies extend the role of these receptors to a natural detoxification process. They coordinate induction of proteins for storage, glucuronidation, and canalicular transport of bilirubin.

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U2 - 10.1016/S1534-5807(03)00131-X

DO - 10.1016/S1534-5807(03)00131-X

M3 - Comment/debate

C2 - 12737794

AN - SCOPUS:0037607405

SN - 1534-5807

VL - 4

SP - 607

EP - 608

JO - Developmental cell

JF - Developmental cell

IS - 5

ER -

Nuclear receptors orchestrate detoxification pathways.

Abstract

ASJC Scopus subject areas

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