Abstract
Background: Nuclear protein in testis (NUT) carcinomas are very rare and have a very poor survival rate. The most common sites of involvement include the nasal cavity, sinus, and mediastinum. Laryngeal NUT midline carcinoma is extremely rare, with only 2 cases reported thus far. Here, we are describing another case of NUT laryngeal carcinoma. Methods and Results: The patient was a light smoker and nondrinker who presented with upper respiratory tract obstruction. Imaging and laryngoscopic evaluation revealed a large intraluminal laryngeal mass. Biopsy demonstrated poorly differentiated carcinoma with intact mucosa and only focal coexpression of CK5/6 and p40. NUT protein immune-stain positivity conclusively established the diagnosis of NUT midline carcinoma. Conclusion: Absence of well-known risk factors, pathologic finding of lack of mucosal involvement and lack of squamous differentiation with poorly differentiated carcinoma, should prompt clinicians to consider this rare entity as a possible diagnosis.
Original language | English (US) |
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Pages (from-to) | E2471-E2474 |
Journal | Head and Neck |
Volume | 38 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1 2016 |
Externally published | Yes |
Keywords
- laryngeal carcinoma
- nuclear protein in testis (NUT) midline carcinoma
ASJC Scopus subject areas
- Otorhinolaryngology