Nuclear protein in testis midline carcinoma of larynx

An underdiagnosed entity

Ajay Kundra, Mirela Andrei, William Westra, Rashid Chaudhry, Harry Moussouris, Arash Gohari, Jen C. Wang, Jonathan Irish

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Nuclear protein in testis (NUT) carcinomas are very rare and have a very poor survival rate. The most common sites of involvement include the nasal cavity, sinus, and mediastinum. Laryngeal NUT midline carcinoma is extremely rare, with only 2 cases reported thus far. Here, we are describing another case of NUT laryngeal carcinoma. Methods and Results: The patient was a light smoker and nondrinker who presented with upper respiratory tract obstruction. Imaging and laryngoscopic evaluation revealed a large intraluminal laryngeal mass. Biopsy demonstrated poorly differentiated carcinoma with intact mucosa and only focal coexpression of CK5/6 and p40. NUT protein immune-stain positivity conclusively established the diagnosis of NUT midline carcinoma. Conclusion: Absence of well-known risk factors, pathologic finding of lack of mucosal involvement and lack of squamous differentiation with poorly differentiated carcinoma, should prompt clinicians to consider this rare entity as a possible diagnosis.

Original languageEnglish (US)
Pages (from-to)E2471-E2474
JournalHead and Neck
Volume38
Issue number8
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Fingerprint

Larynx
Nuclear Proteins
Testis
Carcinoma
Paranasal Sinuses
Nasal Cavity
Mediastinum
Respiratory System
Mucous Membrane
Coloring Agents
Survival Rate
Biopsy
Proteins

Keywords

  • laryngeal carcinoma
  • nuclear protein in testis (NUT) midline carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Kundra, A., Andrei, M., Westra, W., Chaudhry, R., Moussouris, H., Gohari, A., ... Irish, J. (2016). Nuclear protein in testis midline carcinoma of larynx: An underdiagnosed entity. Head and Neck, 38(8), E2471-E2474. https://doi.org/10.1002/hed.24418

Nuclear protein in testis midline carcinoma of larynx : An underdiagnosed entity. / Kundra, Ajay; Andrei, Mirela; Westra, William; Chaudhry, Rashid; Moussouris, Harry; Gohari, Arash; Wang, Jen C.; Irish, Jonathan.

In: Head and Neck, Vol. 38, No. 8, 01.08.2016, p. E2471-E2474.

Research output: Contribution to journalArticle

Kundra, A, Andrei, M, Westra, W, Chaudhry, R, Moussouris, H, Gohari, A, Wang, JC & Irish, J 2016, 'Nuclear protein in testis midline carcinoma of larynx: An underdiagnosed entity', Head and Neck, vol. 38, no. 8, pp. E2471-E2474. https://doi.org/10.1002/hed.24418
Kundra A, Andrei M, Westra W, Chaudhry R, Moussouris H, Gohari A et al. Nuclear protein in testis midline carcinoma of larynx: An underdiagnosed entity. Head and Neck. 2016 Aug 1;38(8):E2471-E2474. https://doi.org/10.1002/hed.24418
Kundra, Ajay ; Andrei, Mirela ; Westra, William ; Chaudhry, Rashid ; Moussouris, Harry ; Gohari, Arash ; Wang, Jen C. ; Irish, Jonathan. / Nuclear protein in testis midline carcinoma of larynx : An underdiagnosed entity. In: Head and Neck. 2016 ; Vol. 38, No. 8. pp. E2471-E2474.
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