Nuclear localization of anti-Hu antibody is not associated with in vitro cytotoxicity

Adília Hormigo, Frank Lieberman

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

IgG fractions of sera containing anti-Hu antibodies or control sera were influenced with Hu-positive and Hu-negative cell lines. Anti-Hu IgG specifically localized in the nucleus of Hu-positive cells. Anti-Hu-positive and control sera were incubated with Hu-positive cells and human complement or peripheral blood mononuclear cells. Hu antibody caused neither complement-mediated lysis nor augmented antibody-dependent cell-mediated cytotoxicity. Anti-Hu IgG did not affect proliferation of Hu-positive cells. Anti-Hu antibodies may not play a direct role in tissue injury in patients with paraneoplastic encephalomyeloneuropathy and anti-Hu antibodies.

Original languageEnglish (US)
Pages (from-to)205-212
Number of pages8
JournalJournal of Neuroimmunology
Volume55
Issue number2
DOIs
StatePublished - Dec 1994
Externally publishedYes

Keywords

  • Anti-Hu antibody
  • Antibody internalization
  • Cell growth
  • Cytotoxicity
  • Paraneoplastic encephalomyeloneuropathy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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