Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection

C. J. Bacchi, Louis M. Weiss, S. Lane, B. Frydman, A. Valasinas, V. Reddy, J. S. Sun, L. J. Marton, I. A. Khan, M. Moretto, N. Yarlett, M. Wittner

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation. We have demonstrated in vitro and in vivo that synthetic polyamine analogs are effective antimicrosporidial agents with a broad therapeutic window. CD8-knockout mice or nude mice infected with the microsporidian Encephalitozoon cuniculi were cured when they were treated with four different novel polyamine analogs at doses ranging from 1.25 to 5 mg/kg of body weight/day for a total of 10 days. Cured animals demonstrated no evidence of parasitemia by either PCR or histologic staining of tissues 30 days after untreated control animals died.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume46
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Microsporidiosis
Polyamines
Acquired Immunodeficiency Syndrome
Encephalitozoon cuniculi
Microsporidia
Parasitemia
Immunocompromised Host
Organ Transplantation
Infection
Nude Mice
Knockout Mice
Body Weight
Staining and Labeling
Polymerase Chain Reaction
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection. / Bacchi, C. J.; Weiss, Louis M.; Lane, S.; Frydman, B.; Valasinas, A.; Reddy, V.; Sun, J. S.; Marton, L. J.; Khan, I. A.; Moretto, M.; Yarlett, N.; Wittner, M.

In: Antimicrobial Agents and Chemotherapy, Vol. 46, No. 1, 2002, p. 55-61.

Research output: Contribution to journalArticle

Bacchi, CJ, Weiss, LM, Lane, S, Frydman, B, Valasinas, A, Reddy, V, Sun, JS, Marton, LJ, Khan, IA, Moretto, M, Yarlett, N & Wittner, M 2002, 'Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection', Antimicrobial Agents and Chemotherapy, vol. 46, no. 1, pp. 55-61. https://doi.org/10.1128/AAC.46.1.55-61.2002
Bacchi, C. J. ; Weiss, Louis M. ; Lane, S. ; Frydman, B. ; Valasinas, A. ; Reddy, V. ; Sun, J. S. ; Marton, L. J. ; Khan, I. A. ; Moretto, M. ; Yarlett, N. ; Wittner, M. / Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection. In: Antimicrobial Agents and Chemotherapy. 2002 ; Vol. 46, No. 1. pp. 55-61.
@article{5cd11205a8b94e93a4b50960b235e048,
title = "Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection",
abstract = "Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation. We have demonstrated in vitro and in vivo that synthetic polyamine analogs are effective antimicrosporidial agents with a broad therapeutic window. CD8-knockout mice or nude mice infected with the microsporidian Encephalitozoon cuniculi were cured when they were treated with four different novel polyamine analogs at doses ranging from 1.25 to 5 mg/kg of body weight/day for a total of 10 days. Cured animals demonstrated no evidence of parasitemia by either PCR or histologic staining of tissues 30 days after untreated control animals died.",
author = "Bacchi, {C. J.} and Weiss, {Louis M.} and S. Lane and B. Frydman and A. Valasinas and V. Reddy and Sun, {J. S.} and Marton, {L. J.} and Khan, {I. A.} and M. Moretto and N. Yarlett and M. Wittner",
year = "2002",
doi = "10.1128/AAC.46.1.55-61.2002",
language = "English (US)",
volume = "46",
pages = "55--61",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "1",

}

TY - JOUR

T1 - Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection

AU - Bacchi, C. J.

AU - Weiss, Louis M.

AU - Lane, S.

AU - Frydman, B.

AU - Valasinas, A.

AU - Reddy, V.

AU - Sun, J. S.

AU - Marton, L. J.

AU - Khan, I. A.

AU - Moretto, M.

AU - Yarlett, N.

AU - Wittner, M.

PY - 2002

Y1 - 2002

N2 - Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation. We have demonstrated in vitro and in vivo that synthetic polyamine analogs are effective antimicrosporidial agents with a broad therapeutic window. CD8-knockout mice or nude mice infected with the microsporidian Encephalitozoon cuniculi were cured when they were treated with four different novel polyamine analogs at doses ranging from 1.25 to 5 mg/kg of body weight/day for a total of 10 days. Cured animals demonstrated no evidence of parasitemia by either PCR or histologic staining of tissues 30 days after untreated control animals died.

AB - Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation. We have demonstrated in vitro and in vivo that synthetic polyamine analogs are effective antimicrosporidial agents with a broad therapeutic window. CD8-knockout mice or nude mice infected with the microsporidian Encephalitozoon cuniculi were cured when they were treated with four different novel polyamine analogs at doses ranging from 1.25 to 5 mg/kg of body weight/day for a total of 10 days. Cured animals demonstrated no evidence of parasitemia by either PCR or histologic staining of tissues 30 days after untreated control animals died.

UR - http://www.scopus.com/inward/record.url?scp=0036137012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036137012&partnerID=8YFLogxK

U2 - 10.1128/AAC.46.1.55-61.2002

DO - 10.1128/AAC.46.1.55-61.2002

M3 - Article

C2 - 11751111

AN - SCOPUS:0036137012

VL - 46

SP - 55

EP - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 1

ER -