Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection

C. J. Bacchi, L. M. Weiss, S. Lane, B. Frydman, A. Valasinas, V. Reddy, J. S. Sun, L. J. Marton, I. A. Khan, M. Moretto, N. Yarlett, M. Wittner

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation. We have demonstrated in vitro and in vivo that synthetic polyamine analogs are effective antimicrosporidial agents with a broad therapeutic window. CD8-knockout mice or nude mice infected with the microsporidian Encephalitozoon cuniculi were cured when they were treated with four different novel polyamine analogs at doses ranging from 1.25 to 5 mg/kg of body weight/day for a total of 10 days. Cured animals demonstrated no evidence of parasitemia by either PCR or histologic staining of tissues 30 days after untreated control animals died.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalAntimicrobial agents and chemotherapy
Volume46
Issue number1
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Bacchi, C. J., Weiss, L. M., Lane, S., Frydman, B., Valasinas, A., Reddy, V., Sun, J. S., Marton, L. J., Khan, I. A., Moretto, M., Yarlett, N., & Wittner, M. (2002). Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection. Antimicrobial agents and chemotherapy, 46(1), 55-61. https://doi.org/10.1128/AAC.46.1.55-61.2002