Novel risk calculator performance in athletes with arrhythmogenic right ventricular cardiomyopathy

Alessio Gasperetti, Antonio Dello Russo, Mattia Busana, Mariantonietta Dessanai, Francesca Pizzamiglio, Ardan Muammer Saguner, Anneline S.J.M. te Riele, Elena Sommariva, Giulia Vettor, Laurens Bosman, Firat Duru, Paolo Zeppilli, Luigi Di Biase, Andrea Natale, Claudio Tondo, Michela Casella

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background: Disease progression and ventricular arrhythmias (VAs) in arrhythmogenic right ventricular cardiomyopathy (ARVC) are correlated with physical exercise, and clinical detraining and avoidance of competitive sport practice are suggested for ARVC patients. An algorithm assessing primary arrhythmic risk in ARVC patients was recently developed by Cadrin-Tourigny et al. Data regarding its transferability to athletes are lacking. Objective: The purpose of this study was to assess the reliability of the Cadrin-Tourigny risk prediction algorithm in a cohort of athletes with ARVC and to describe the impact of clinical detraining on disease progression. Methods: All athletes undergoing clinical detraining after ARVC diagnosis at our institution were enrolled. Baseline and follow-up clinical characteristics and data on VA events occurring during follow-up were collected. The Cadrin-Tourigny algorithm was used to calculate the a priori predicted VA risk, which was compared with the observed outcomes. Results: Twenty-five athletes (age 36.1 ± 14.0 years; 80% male) with definite ARVC who were undergoing clinical detraining were enrolled. Over median (interquartile range) follow-up of 5.3 (3.2–6.6) years, a reduction in premature ventricular complex (PVC) burden (P =.001) was assessed, and 10 VA events (40%) were recorded. The a priori algorithm-predicted risk seemed to fit with the observed cohort arrhythmic risk [mean observed–predicted risk difference over 5 years –0.85% (interquartile range –4.8% to +3.1%); P =.85]. At 1-year follow-up, 11 patients (44%) had an improved stress ECG response, and no significant changes in right ventricular ejection fraction were observed. Conclusion: Clinical detraining is associated with PVC burden reduction in athletes with ARVC. The novel risk prediction algorithm does not seem to require any correction for its application to ARVC athletes.

Original languageEnglish (US)
Pages (from-to)1251-1259
Number of pages9
JournalHeart Rhythm
Issue number8
StatePublished - Aug 2020


  • Arrhythmogenic right ventricular cardiomyopathy
  • Athletes
  • Clinical detraining
  • Physical exercise
  • Risk calculator
  • Ventricular arrhythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'Novel risk calculator performance in athletes with arrhythmogenic right ventricular cardiomyopathy'. Together they form a unique fingerprint.

Cite this